Genetic Risk Factors for Depression in Alzheimer´s Disease Patients

Title:Genetic Risk Factors for Depression in Alzheimer´s Disease Patients

Volume: 10 Issue: 1

Author(s): Sonke Arlt, Cuneyt Demiralay, Bjorn Tharun, Olga Geisel, Niels Storm, Martin Eichenlaub, Jan T. Lehmbeck, Klaus Wiedemann, Boris Leuenberger and Holger Jahn

Affiliation:

Keywords: Alzheimer´s Disease, Comorbidity, Dementia, Genetic Polymorphism, Genetic Risk Factor, Major Depression

Abstract: Objective: Alzheimer´s Disease (AD) is often associated with depressive symptoms developing at any time before and after AD onset. The aetiology of depression in AD has not sufficiently been characterized, but biological aspects due to neurodegeneration and/ or genetic risk factors may play a plausible role and may distinguish it from common depressive disorders.

Method: To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.

Results: Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780). There was an increased risk of having MDD in homozygous female carriers of the TPH1 A-allele (odds ratio: 4.35) and homozygous carriers of the MAOA VNTR low activity allele 3R (odds ratio: 3.37).

Conclusion: We detected allelic or genotypic associations of MAOA, TPH1, FKBP5 and BDNF in clinically significant MDD in AD. Odds-ratios were generally higher in female AD-patients, which might be due to the composition of the study population. Further studies on the neurotransmitter systems affected by the genetic polymorphisms found to be associated with MDD in AD may help to elucidate the underlying pathomechanisms of MDD.

Cite this article as:

Arlt Sonke, Demiralay Cuneyt, Tharun Bjorn, Geisel Olga, Storm Niels, Eichenlaub Martin, T. Lehmbeck Jan, Wiedemann Klaus, Leuenberger Boris and Jahn Holger, Genetic Risk Factors for Depression in Alzheimer´s Disease Patients, Current Alzheimer Research 2013; 10 (1) . https://dx.doi.org/10.2174/1567205011310010010

DOI https://dx.doi.org/10.2174/1567205011310010010	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828