摘要
目前,实验和临床证据表明像富含多酚类的天然产品,如保健品和食品补充剂,由于其生物特性,可为2型糖尿病提供独特的治疗。天然产物通过多种机制调节碳水化合物的代谢,如恢复beta细胞的完整性和生理性、增强胰岛素释放活动和葡萄糖使用。沙棘浆果、红葡萄、越桔、野樱桃和像可可、咖啡和绿茶等受欢迎的饮料都富含多酚类物质,并可能降低胰岛素反应,为糖尿病治疗提供天然替代品。因此,现在的研究都关注于不同类型的多酚类物质的潜在功效,包括黄酮、酚酸、木脂素、花青素和芪类。动物和人类研究表明多酚调节碳水化合物和脂质代谢、降低血糖和胰岛素抵抗、增加脂质代谢和优化氧化应激和炎症过程。以便指导糖尿病患者的有效治疗干预,熟悉富含多酚类提取物补充剂的合适剂量和持续时间很重要。
关键词: 多酚类,天然产品,2型糖尿病。
Current Medicinal Chemistry
Title:Polyphenols-Rich Natural Products for Treatment of Diabetes
Volume: 22 Issue: 1
Author(s): S. Dragan, F. Andrica, Maria-Corina Serban and R. Timar
Affiliation:
关键词: 多酚类,天然产品,2型糖尿病。
摘要: Currently, experimental and clinical evidences showed that polyphenols-rich natural products, like nutraceuticals and food supplements, may offer unique treatment modalities in type 2 diabetes mellitus (DM), due to their biological properties. Natural products modulate the carbohydrate metabolism by various mechanisms, such as restoring beta-cells integrity and physiology, enhancing insulin releasing activity, and the glucose using. Sea buckthorn berries, red grapes, bilberries, chokeberries and popular drinks like cocoa, coffee and green tea are all rich in polyphenols and may decrease the insulin response, offerin g a natural alternative of treatment in diabetes. Therefore, researches are now focused on potential efficacies of different types of polyphenols, including flavonoids, phenolic acids, lignans, anthocyans and stilbenes. Animal and human studies showed that polyphenols modulate carbohydrate and lipid metabolism, decrease glycemia and insulin resistance, increase lipid metabolism and optimize oxidative stress and inflammatory processes. It is important to understand the proper dose and duration of supplementation with polyphenols-rich extracts in order to guide effective therapeutic interventions in diabetic patients.
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Cite this article as:
S. Dragan, F. Andrica, Maria-Corina Serban and Timar R., Polyphenols-Rich Natural Products for Treatment of Diabetes, Current Medicinal Chemistry 2015; 22 (1) . https://dx.doi.org/10.2174/0929867321666140826115422
DOI https://dx.doi.org/10.2174/0929867321666140826115422 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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