Design, Synthesis and Antitubercular Evaluation of New 2-amino-5-(4- (benzyloxy)benzyl)thiophene-3-carboxylic Acid Derivatives. Part 3

Title:Design, Synthesis and Antitubercular Evaluation of New 2-amino-5-(4- (benzyloxy)benzyl)thiophene-3-carboxylic Acid Derivatives. Part 3

Volume: 12 Issue: 1

Author(s): Xiaoyun Lu, Jian Tang, Qidong You, Baojie Wan and Scott G. Franzblau

Affiliation:

Keywords: 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives, antitubercular activity, design and synthesis, MIC, microplate Alamar Blue Assay (MABA), tuberculosis.

Abstract: A series of 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives was designed and synthesized. The derivatives were evaluated for antitubercular activity against M. tuberculosis ATCC 27294 using the Microplate Alamar Blue Assay (MABA). Among them, compound 8b exhibited the most potent activity with MIC value of 1.9 µM.

Cite this article as:

Lu Xiaoyun, Tang Jian, You Qidong, Wan Baojie and Franzblau G. Scott, Design, Synthesis and Antitubercular Evaluation of New 2-amino-5-(4- (benzyloxy)benzyl)thiophene-3-carboxylic Acid Derivatives. Part 3, Letters in Drug Design & Discovery 2015; 12 (1) . https://dx.doi.org/10.2174/1570180811666140812231321

DOI https://dx.doi.org/10.2174/1570180811666140812231321	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X