Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives

Title:Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives

Volume: 11 Issue: 2

Author(s): Iyadh Aouani, Karima Lahbib and Soufiane Touil

Affiliation:

Keywords: α-Hydroxyphosphonates, γ-cyano-α-hydroxyphosphonates, γ-ketonitriles, green synthesis, antioxidant activity.

Abstract: Herein we report an efficient, simple and green synthesis of novel types of α-hydroxyphosphonates bearing a nitrile group, from the reaction of γ-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2- picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.

Cite this article as:

Aouani Iyadh, Lahbib Karima and Touil Soufiane, Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives, Medicinal Chemistry 2015; 11 (2) . https://dx.doi.org/10.2174/1573406410666140706154046