Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

Title:Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

Volume: 11 Issue: 2

Author(s): Shouxin Liu, Jun Feng, He Liu, Junzhang Li and Xia Tian

Affiliation:

Keywords: Acylation compound, antitumor, britannilactone, synthesis.

Abstract: N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by ¹HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC₅₀ values of compound IVg were 2.7 μM and 4.3 μM, respectively.

Cite this article as:

Liu Shouxin, Feng Jun, Liu He, Li Junzhang and Tian Xia, Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone, Medicinal Chemistry 2015; 11 (2) . https://dx.doi.org/10.2174/1573406410666140815123216