摘要
维生素D是一种调节矿物质平衡,骨代谢和许多其他生理学过程的甾类激素。维生素D的活性代谢物,1α, 25-二羟基维生素D(1,25D3)具有广谱的抗癌活性和增强许多其他化疗药物疗效的作用。1,25D3主要通过基因机制包括通过维生素D应答元素(VDREs)而发挥的基因转录调节作用来发挥其抗癌作用。最近,微小核糖核酸发现其由1,25D3调控。微小核糖核酸是一些短的非编码RNAs,在转录后期能够调节大量基因的表达。因此,在多种疾病包括癌症的发生和发展过程中,它们具有重要的调控作用。这篇综述主要阐述在癌症模型系统中由1,25D3调控的微小核糖核酸的表达,以及 1,25D3在调控微小核糖核酸发挥抗癌效应中的贡献。此外,微小核糖核酸对1,25D3信号传导的影响也被讨论了。
关键词: 骨化三醇,癌症,微小核糖核酸,维生素D
Current Gene Therapy
Title:Vitamin D and miRNAs in Cancer
Volume: 14 Issue: 4
Author(s): Yingyu Ma, Donald L. Trump and Candace S. Johnson
Affiliation:
关键词: 骨化三醇,癌症,微小核糖核酸,维生素D
摘要: Vitamin D is a steroid hormone that regulates mineral homeostasis, bone metabolism and many other physiological processes. The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D (1,25D3), has broad spectrum antitumor activities and potentiates the effects of a number of chemotherapeutic agents. 1,25D3 exerts its anti-tumor effects mainly through genomic mechanisms involving the regulation of gene transcription through vitamin D response elements (VDREs). More recently, miRNAs have been shown to be regulated by 1,25D3. miRNAs are short non-coding RNAs that post-transcriptionally modulate the expression of a wide range of genes. Therefore, they have important regulatory roles in the development and progression of many diseases including cancer. This review focuses on the regulation of miRNA expression by 1,25D3 in cancer model systems and the contribution of the regulated miRNAs to the anti-tumor effect of 1,25D3. In addition, the impact of miRNAs on 1,25D3 signaling is discussed.
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Ma Yingyu, Trump L. Donald and Johnson S. Candace, Vitamin D and miRNAs in Cancer, Current Gene Therapy 2014; 14 (4) . https://dx.doi.org/10.2174/1566523214666140612153537
DOI https://dx.doi.org/10.2174/1566523214666140612153537 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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