Vitamin D and miRNAs in Cancer

Title:Vitamin D and miRNAs in Cancer

Volume: 14 Issue: 4

Author(s): Yingyu Ma, Donald L. Trump and Candace S. Johnson

Affiliation:

Keywords: calcitriol, cancer, microRNA, vitamin D.

Abstract: Vitamin D is a steroid hormone that regulates mineral homeostasis, bone metabolism and many other physiological processes. The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D (1,25D₃), has broad spectrum antitumor activities and potentiates the effects of a number of chemotherapeutic agents. 1,25D₃ exerts its anti-tumor effects mainly through genomic mechanisms involving the regulation of gene transcription through vitamin D response elements (VDREs). More recently, miRNAs have been shown to be regulated by 1,25D₃. miRNAs are short non-coding RNAs that post-transcriptionally modulate the expression of a wide range of genes. Therefore, they have important regulatory roles in the development and progression of many diseases including cancer. This review focuses on the regulation of miRNA expression by 1,25D₃ in cancer model systems and the contribution of the regulated miRNAs to the anti-tumor effect of 1,25D₃. In addition, the impact of miRNAs on 1,25D₃ signaling is discussed.

Cite this article as:

Ma Yingyu, Trump L. Donald and Johnson S. Candace, Vitamin D and miRNAs in Cancer, Current Gene Therapy 2014; 14 (4) . https://dx.doi.org/10.2174/1566523214666140612153537