Abstract
The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.
Keywords: Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea, somatostatin agonists, topoisomerase inhibitors.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Recent Developments on Thiourea Based Anticancer Chemotherapeutics
Volume: 15 Issue: 2
Author(s): Vikas Kumar and Swapandeep Singh Chimni
Affiliation:
Keywords: Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea, somatostatin agonists, topoisomerase inhibitors.
Abstract: The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.
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Cite this article as:
Kumar Vikas and Chimni Singh Swapandeep, Recent Developments on Thiourea Based Anticancer Chemotherapeutics, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (2) . https://dx.doi.org/10.2174/1871520614666140407123526
DOI https://dx.doi.org/10.2174/1871520614666140407123526 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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