Abstract
Currently, it is well-known that changes in the maternal metabolic status induce changes in the intrauterine environment and modify the metabolic status of the fetuses, playing a key role in the growth, life-time fitness/obesity and probability of appearance of metabolic disorders in the offspring. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations either exposed (multigenerational exposure) or unexposed (intergenerational or transgenerational inheritance) to such metabolic defies, perpetuating the problem. Thus, having in mind the impact on worldwide public health, the present review outlines, based on results of translational animal research and clinical human studies, the mechanisms, pathways and practical implications involved in the transgenerational inheritance of the metabolic syndrome.
Keywords: Developmental-programming, epigenetics, fetal-hypoxia, fetal-metabolism, metabolic-syndrome, placentalefficiency, transgenerational-programming.
Current Pharmaceutical Biotechnology
Title:Transgenerational Inheritance in the Offspring of Pregnant Women with Metabolic Syndrome
Volume: 15 Issue: 1
Author(s): Antonio Gonzalez-Bulnes, Cristina Ovilo and Susana Astiz
Affiliation:
Keywords: Developmental-programming, epigenetics, fetal-hypoxia, fetal-metabolism, metabolic-syndrome, placentalefficiency, transgenerational-programming.
Abstract: Currently, it is well-known that changes in the maternal metabolic status induce changes in the intrauterine environment and modify the metabolic status of the fetuses, playing a key role in the growth, life-time fitness/obesity and probability of appearance of metabolic disorders in the offspring. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations either exposed (multigenerational exposure) or unexposed (intergenerational or transgenerational inheritance) to such metabolic defies, perpetuating the problem. Thus, having in mind the impact on worldwide public health, the present review outlines, based on results of translational animal research and clinical human studies, the mechanisms, pathways and practical implications involved in the transgenerational inheritance of the metabolic syndrome.
Export Options
About this article
Cite this article as:
Gonzalez-Bulnes Antonio, Ovilo Cristina and Astiz Susana, Transgenerational Inheritance in the Offspring of Pregnant Women with Metabolic Syndrome, Current Pharmaceutical Biotechnology 2014; 15 (1) . https://dx.doi.org/10.2174/1389201015666140330192009
DOI https://dx.doi.org/10.2174/1389201015666140330192009 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Progress in the Development of Natural ent-Kaurane Diterpenoids with Anti-tumor Activity
Mini-Reviews in Medicinal Chemistry Epidemiological Aspects of Stroke in Very Old Patients
Cardiovascular & Hematological Disorders-Drug Targets Radiolabelled Peptides and Monoclonal Antibodies for Therapy Decision Making in Inflammatory Diseases
Current Pharmaceutical Design Surgery for Severe Obesity: Indications, Techniques, Mechanisms of Weight Loss and Diabetes Resolution
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report
Current Protein & Peptide Science Mechanisms Involved in the Genesis of Diabetic Nephropathy
Current Diabetes Reviews Therapeutic Use of Vitamin D and its Analogues in Autoimmunity
Recent Patents on Inflammation & Allergy Drug Discovery Potential Application of Centrifuges to Protect the CNS in Space and on Earth
Current Alzheimer Research Outcome Measures for Clinical Trials in Interstitial Lung Diseases
Current Respiratory Medicine Reviews Five Markers Capable to Identify Passive Smoking Exposure Associated with Endothelial Dysfunction in Healthy Individuals
Current Hypertension Reviews Melatonin, a Potential Therapeutic Agent for Smooth Muscle-Related Pathological Conditions and Aging
Current Medicinal Chemistry Interaction studies of Withania somnifera’s key metabolite Withaferin A with different receptors associated with cardiovascular disease
Current Computer-Aided Drug Design Systemic Sclerosis Associated Interstitial Lung Disease
Current Respiratory Medicine Reviews Peptides Targeting Angiogenesis Related Growth Factor Receptors
Current Pharmaceutical Design Elevated Inflammatory Parameter Levels Negatively Impact Populations of Circulating Stem Cells (CD133+), Early Endothelial Progenitor Cells (CD133+/VEGFR2+), and Fibroblast Growth Factor in Stroke Patients
Current Neurovascular Research Current Status of Carotid Stenting
Current Vascular Pharmacology Update on Diagnostic and Treatment of Uncomplicated and Complicated Malaria in Adults and Selected Vulnerable Populations
Infectious Disorders - Drug Targets From Endothelial Dysfunction to Arterial Stiffness in Diabetes Mellitus
Current Diabetes Reviews Basic Approaches in Therapy of Multiple Sclerosis (MS) and Related Diseases: Current Achievement and Prospective
Central Nervous System Agents in Medicinal Chemistry Glucose Tolerance Status in Pregnancy: A Window to the Future Risk of Diabetes and Cardiovascular Disease in Young Women
Current Diabetes Reviews