Abstract
Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not been elucidated, it has been reported that high levels of endoglin, a TGF-β auxiliary co-receptor, and a soluble form of this protein, occur respectively in the placenta and plasma of women who develop the disease. In this review, the alterations in vasculogenesis and angiogenesis that occur during preeclampsia, the cellular and molecular mechanisms that lead to increased membrane bound endoglin expression and soluble endoglin release, including hypoxia and oxidative stress, and the possible pathogenic role of soluble endoglin in this disease have been analyzed.
Keywords: Endoglin, endothelial dysfunction, hypertension, hypoxia, oxidative stress, placenta, preeclampsia, soluble endoglin.
Current Molecular Medicine
Title:Membrane and Soluble Forms of Endoglin in Preeclampsia
Volume: 13 Issue: 8
Author(s): B. Oujo, F. Perez-Barriocanal, C. Bernabeu and J. M. Lopez-Novoa
Affiliation:
Keywords: Endoglin, endothelial dysfunction, hypertension, hypoxia, oxidative stress, placenta, preeclampsia, soluble endoglin.
Abstract: Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not been elucidated, it has been reported that high levels of endoglin, a TGF-β auxiliary co-receptor, and a soluble form of this protein, occur respectively in the placenta and plasma of women who develop the disease. In this review, the alterations in vasculogenesis and angiogenesis that occur during preeclampsia, the cellular and molecular mechanisms that lead to increased membrane bound endoglin expression and soluble endoglin release, including hypoxia and oxidative stress, and the possible pathogenic role of soluble endoglin in this disease have been analyzed.
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Oujo B., Perez-Barriocanal F., Bernabeu C. and Lopez-Novoa M. J., Membrane and Soluble Forms of Endoglin in Preeclampsia, Current Molecular Medicine 2013; 13 (8) . https://dx.doi.org/10.2174/15665240113139990058
DOI https://dx.doi.org/10.2174/15665240113139990058 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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