Spectral Features and In Vitro Antioxidant Study of Nanoscale Solid Dispersions of Different Sizes of Coenzyme Q10 (CoQ10) Prepared by Heat Melt and High-pressure Homogenization Method

Yunlong      Ge; Xiuhua      Zhao; Song      Wang; Yuangang      Zu; Qingyong      Li; Mei      Sang; Xiaoyu      Sui; Kunlun      Wang

doi:10.2174/15734137113099990055

Abstract

Coenzyme Q₁₀ (CoQ₁₀) has been reported as a powerful antioxidant in plasma. Recent in vivo investigations showed that cosmetically applied CoQ₁₀ can reduce photo-aging. However, CoQ₁₀ was barely satisfactory in topical drug delivery because of its poor solubility and high molecular weight. To improve the anti-oxidative efficiency of CoQ₁₀ in skin photo-aging, a novel water-soluble nanoscale solid dispersion of CoQ₁₀ (CoQ₁₀-SD) was prepared by heat melt and high-pressure homogenization method in the present study. Three sizes of CoQ₁₀-SDs were obtained and characterized. The spectral investigations showed that the smaller particle size solution of CoQ₁₀-SD was more effective against ultraviolet (UV) radiation. The UVB radiation absorption and reflection of the CoQ₁₀-SD solution increased with increasing concentration and decreasing particle size. The in vitro antioxidants of CoQ₁₀-SD were also assessed. The results showed that, smaller particle size results in higher antioxidant effect. A lower level of intracellular reactive oxygen species was found when the myocardial cells were treated with CoQ₁₀-SD of smaller size. These ndings indicated that CoQ₁₀-SD can be an effective cosmetic delivery system to protect the skin from early aging induced by UV.