Abstract
In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.
Keywords: Adult stem cells, bone deficiencies, bone engineering, embryonic-derived progenitors, human embryonic stem cells, human skeleton, mesenchymal stem cells.
Current Molecular Medicine
Title:Human Progenitor Cells for Bone Engineering Applications
Volume: 13 Issue: 5
Author(s): G.M. de Peppo, P. Thomsen, C. Karlsson, R. Strehl, A. Lindahl and J. Hyllner
Affiliation:
Keywords: Adult stem cells, bone deficiencies, bone engineering, embryonic-derived progenitors, human embryonic stem cells, human skeleton, mesenchymal stem cells.
Abstract: In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.
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Cite this article as:
Peppo G.M. de, Thomsen P., Karlsson C., Strehl R., Lindahl A. and Hyllner J., Human Progenitor Cells for Bone Engineering Applications, Current Molecular Medicine 2013; 13 (5) . https://dx.doi.org/10.2174/1566524011313050004
DOI https://dx.doi.org/10.2174/1566524011313050004 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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