Abstract
Plasmalogens are unique vinyl ether glycerophospholipids that serve diverse structural roles in the membranes of cells and cell organelles. Additionally, the fatty acid substitutions at sn– 2 of the glycerol backbone are dynamically removed by lipases and replaced by acyltransferases. These fatty acid storage pools provide the free arachidonic acid and docosahexaenoic acid (DHA) involved in signal transduction cascades.
The biosynthesis of plasmalogens critically involves the generation of the ether lipid substitution at sn–1 of the glycerol backbone. This step only occurs in peroxisomes and is dysfunctional in genetic peroxisomal disorders and in several diseases of aging.
A number of approaches have been undertaken to augment plasmalogen levels in these clinical conditions. In this review we present the current status of alkylglycerol precursors that bypass the requirement of the peroxisomal compartment.
Keywords: Alkylglycerol, Ecomer, krill oil, DHA, plasmalogen, peroxisome.
Current Organic Chemistry
Title:Alkylglycerol Lipid Precursors: A Review of Therapeutic Strategies for Plasmalogen Replacement
Volume: 17 Issue: 8
Author(s): Paul L. Wood
Affiliation:
Keywords: Alkylglycerol, Ecomer, krill oil, DHA, plasmalogen, peroxisome.
Abstract: Plasmalogens are unique vinyl ether glycerophospholipids that serve diverse structural roles in the membranes of cells and cell organelles. Additionally, the fatty acid substitutions at sn– 2 of the glycerol backbone are dynamically removed by lipases and replaced by acyltransferases. These fatty acid storage pools provide the free arachidonic acid and docosahexaenoic acid (DHA) involved in signal transduction cascades.
The biosynthesis of plasmalogens critically involves the generation of the ether lipid substitution at sn–1 of the glycerol backbone. This step only occurs in peroxisomes and is dysfunctional in genetic peroxisomal disorders and in several diseases of aging.
A number of approaches have been undertaken to augment plasmalogen levels in these clinical conditions. In this review we present the current status of alkylglycerol precursors that bypass the requirement of the peroxisomal compartment.
Export Options
About this article
Cite this article as:
Wood Paul L., Alkylglycerol Lipid Precursors: A Review of Therapeutic Strategies for Plasmalogen Replacement, Current Organic Chemistry 2013; 17 (8) . https://dx.doi.org/10.2174/1385272811317080004
DOI https://dx.doi.org/10.2174/1385272811317080004 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein
Protein & Peptide Letters Vitamin D and Vitamin D Receptor Activators in Treatment of Hypertension and Cardiovascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?
Current Pharmaceutical Design Editorial:Advanced Methods of Biomedical Signal Processing for Early Detection of Alzheimer`s Disease
Current Alzheimer Research Editorial (Thematic Issue: Alzheimer’s Disease - Mechanisms, Drug Targets and Alternative Treatments)
Current Topics in Medicinal Chemistry Start Small and Stay Small: Minimizing Attrition in the Clinic with a Focus on CNS Therapeutics
Current Topics in Medicinal Chemistry PDE5 Inhibitors in Non-Urological Conditions
Current Pharmaceutical Design Hybrid SPECT/CT Imaging in Neurology
Current Radiopharmaceuticals Fused 1,4-Dihydropyridines as Potential Calcium Modulatory Compounds
Mini-Reviews in Medicinal Chemistry Solvent-Free Synthesis of 4,5-Dihydropyrano[c]chromene Derivatives Over TiO<sub>2</sub> Nanoparticles as an Economical and Efficient Catalyst
Current Catalysis Prospective Role of MicroRNAs in Depression
Current Medicinal Chemistry Sirtuins: Common Targets in Aging and in Neurodegeneration
Current Drug Targets Deep Learning: A Breakthrough in Medical Imaging
Current Medical Imaging Aquaporin-1 and Sodium-Hydrogen Exchangers as Pharmacological Targets in Diabetic Atherosclerosis
Current Drug Targets APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice
Current Alzheimer Research SPECT Radiopharmaceuticals for Dementia
Current Radiopharmaceuticals Phytocannabinoids and Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Novel Target Sites for Drug Screening: A Special Reference to Cancer, Rheumatoid Arthritis and Parkinson’s Disease
Current Signal Transduction Therapy Biomarkers of Senescence during Aging as Possible Warnings to Use Preventive Measures
Current Medicinal Chemistry The Complex Link Between Schizophrenia and Dementia: Targeting Ca2+/cAMP Signalling
Current Pharmaceutical Design