Studies of NVP-BEZ235 in Melanoma

Joshua      A. Sznol; Lucia      B. Jilaveanu; Harriet      M. Kluger

doi:10.2174/1568009611313020006

Abstract

The PI3k pathway represents an attractive target for drug development in melanoma, as numerous studies have shown that this pathway is active in malignant melanocytes. In addition, previous work has shown that multi-level targeting of this pathway might be more effective than targeting the pathway at a single level. In this review, we discuss targeting different members of this pathway, potential escape mechanisms, classes of specific molecular inhibitors, and development of NVP-BEZ235, a novel dual PI3k/mTOR inhibitor.

Keywords: Mammalian target of rapamycin, melanoma, phosphatidylinositol 3-kinase.

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