The PI3 Kinase Signaling Pathway in Prostate Cancer

Title:The PI3 Kinase Signaling Pathway in Prostate Cancer

Volume: 13 Issue: 2

Author(s): Aymen A. Elfiky and Zhenyang Jiang

Affiliation:

Keywords: Androgen receptor, mammalian target of rapamycin, phosphatidylinositol 3-kinase, prostate cancer, PTEN.

Abstract: Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is increasingly implicated in a number of malignancies, including prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the therapeutic implications of targeting it.

Cite this article as:

A. Elfiky Aymen and Jiang Zhenyang, The PI3 Kinase Signaling Pathway in Prostate Cancer, Current Cancer Drug Targets 2013; 13 (2) . https://dx.doi.org/10.2174/1568009611313020005