Abstract
Epigenetic modification refers to heritable changes in genotypes or phenotypes through biochemical modifications without altering the underlying DNA sequence. In humans, DNA methylation is a major epigenetic modification that adds a methyl group mainly to the carbon-5 position of the cytosine pyrimidine ring in the cytosine guanine dinucleotide. This epigenetic modification is crucial to normal development and cellular differentiation as well as a number of key processes including genomic imprinting, X-chromosome inactivation, suppression of repetitive elements, and tumorigenesis. Recently, a lot of resources and efforts have been devoted to the DNA methylation profiling of human genome based on biochemical experiments or computational prediction. Here, we provide a review on these experimental and computational techniques, and large-scaled DNA methylation data sets and databases. While the description of the biochemical techniques is mainly to provide an overview of the biological background, we focus more on the computational techniques, particularly on the data resources, methodologies and problems that have been studied. Our goal is to provide a guidance for future bioinformatics research on DNA methylation.
Keywords: DNA methylation, computational epigenetics, prediction, Bisulfite Conversion, Enzyme, lymphoblastoid cell, skeletal muscle, fetal liver, pancreas,
Current Bioinformatics
Title:A Review on the Techniques for Characterizing and Predicting Human Genomic DNA Methylation
Volume: 8 Issue: 2
Author(s): Hao Zheng, Shi-Wen Jiang and Hongwei Wu
Affiliation:
Keywords: DNA methylation, computational epigenetics, prediction, Bisulfite Conversion, Enzyme, lymphoblastoid cell, skeletal muscle, fetal liver, pancreas,
Abstract: Epigenetic modification refers to heritable changes in genotypes or phenotypes through biochemical modifications without altering the underlying DNA sequence. In humans, DNA methylation is a major epigenetic modification that adds a methyl group mainly to the carbon-5 position of the cytosine pyrimidine ring in the cytosine guanine dinucleotide. This epigenetic modification is crucial to normal development and cellular differentiation as well as a number of key processes including genomic imprinting, X-chromosome inactivation, suppression of repetitive elements, and tumorigenesis. Recently, a lot of resources and efforts have been devoted to the DNA methylation profiling of human genome based on biochemical experiments or computational prediction. Here, we provide a review on these experimental and computational techniques, and large-scaled DNA methylation data sets and databases. While the description of the biochemical techniques is mainly to provide an overview of the biological background, we focus more on the computational techniques, particularly on the data resources, methodologies and problems that have been studied. Our goal is to provide a guidance for future bioinformatics research on DNA methylation.
Export Options
About this article
Cite this article as:
Zheng Hao, Jiang Shi-Wen and Wu Hongwei, A Review on the Techniques for Characterizing and Predicting Human Genomic DNA Methylation, Current Bioinformatics 2013; 8 (2) . https://dx.doi.org/10.2174/1574893611308020002
DOI https://dx.doi.org/10.2174/1574893611308020002 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
(Iso)Flav(an)ones, Chalcones, Catechins, and Theaflavins as Anticarcinogens: Mechanisms, Anti-Multidrug Resistance and QSAR Studies
Current Medicinal Chemistry Mesenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson's Disease
Current Stem Cell Research & Therapy Advances in the Researches on the Biological Activities and Inhibitors of Phosphatidylinositol 3-kinase
Anti-Cancer Agents in Medicinal Chemistry PET Radioligands for In Vivo Visualization of Neuroinflammation
Current Pharmaceutical Design The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas
Current Cancer Drug Targets Bioavailability Challenges Associated with Development of Anti-Cancer Phenolics
Mini-Reviews in Medicinal Chemistry Nonsteroidal Aromatase Inhibitors for the Treatment of Breast Cancer: An Update
Anti-Cancer Agents in Medicinal Chemistry Changes in Expression Pattern of SEMA3F Depending on Endometrial Cancer Grade - Pilot Study
Current Pharmaceutical Biotechnology Identification of Prognostic Biomarkers in Papillary Thyroid Cancer and Developing Non-Invasive Diagnostic Models Through Integrated Bioinformatics Analysis
MicroRNA Update on the Development of microRNA and siRNA Molecules as Regulators of Cell Physiology
Recent Patents on DNA & Gene Sequences Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery
Current Medicinal Chemistry An Overview on 2-arylquinolin-4(1H)-ones and Related Structures as Tubulin Polymerisation Inhibitors
Current Topics in Medicinal Chemistry Inhibitory Effects of Bisphosphonates on the Proliferation of Human Ovarian Cancer Cell Lines and the Mechanism
Medicinal Chemistry Counselling and Cognitive Behaviour Interventions Delivered to Reduce Psychological Morbidity and Improve Quality of Life in Gynaecological Cancer Patients: Recent Achievements
Current Women`s Health Reviews Molecular and Cellular Activities of Vitamin E Analogues
Mini-Reviews in Medicinal Chemistry The Pharmacological Pathways of GnRH Mediating the Inhibition of Mammary Tumours: Implications in Humans and Domestic Animals
Current Medicinal Chemistry Identification of AHSA1 as a Potential Therapeutic Target for Breast Cancer: Bioinformatics Analysis and <i>in vitro</i> Studies
Current Cancer Drug Targets Treatment of Estrogen Receptor-Positive Breast Cancer
Current Medicinal Chemistry Microsatellite Instability (MSI) as Genomic Marker in Endometrial Cancer: Toward Scientific Evidences
Mini-Reviews in Medicinal Chemistry Defining the Role of Integrin αvβ6 in Cancer
Current Drug Targets