Abstract
Oral mucositis is a consequence of the toxic effects of chemotherapeutic agents and irradiation on oral mucosa cells. It is estimated that oral mucositis is a complication in 40% of patients receiving chemotherapy, more than 90% of those irradiated for head and neck cancer. This condition is frequently associated with severe pain and inflammation and can cause malnutrition, systemic infections, and low quality of life, as well as limiting chemotherapy doses. The pineal hormone melatonin inhibits the production of free radicals that mediate the toxicity of chemotherapy.
The main objectives of this study is to develop and evaluate a novel occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and melatonin in order to exploit natural biomaterials as functional biocompatible gels and evaluate the performance of the alternative drug delivery system towards in-vitro generated free-radical mediated inflammation response as a model system for oral mucosatis.
Keywords: Free radicals, Melatonin, Chitosan, Oral mucosatis, Hydrogels, In vitro, prototype, homogeneously, supramolecular host-guest recognition, Chitosan, transformation, biocompatible.
Current Organic Chemistry
Title:Novel Melatonin-chitosan Hydrogels as Suitable Oral Bio-drug Delivery Systems to Fight Oral Mucositis: Synergy of Antioxidants and Bioactives in Action
Volume: 16 Issue: 20
Author(s): Victoria T. Perchyonok, Shengmiao Zhang and Theunis Oberholzer
Affiliation:
Keywords: Free radicals, Melatonin, Chitosan, Oral mucosatis, Hydrogels, In vitro, prototype, homogeneously, supramolecular host-guest recognition, Chitosan, transformation, biocompatible.
Abstract: Oral mucositis is a consequence of the toxic effects of chemotherapeutic agents and irradiation on oral mucosa cells. It is estimated that oral mucositis is a complication in 40% of patients receiving chemotherapy, more than 90% of those irradiated for head and neck cancer. This condition is frequently associated with severe pain and inflammation and can cause malnutrition, systemic infections, and low quality of life, as well as limiting chemotherapy doses. The pineal hormone melatonin inhibits the production of free radicals that mediate the toxicity of chemotherapy.
The main objectives of this study is to develop and evaluate a novel occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and melatonin in order to exploit natural biomaterials as functional biocompatible gels and evaluate the performance of the alternative drug delivery system towards in-vitro generated free-radical mediated inflammation response as a model system for oral mucosatis.
Export Options
About this article
Cite this article as:
T. Perchyonok Victoria, Zhang Shengmiao and Oberholzer Theunis, Novel Melatonin-chitosan Hydrogels as Suitable Oral Bio-drug Delivery Systems to Fight Oral Mucositis: Synergy of Antioxidants and Bioactives in Action, Current Organic Chemistry 2012; 16 (20) . https://dx.doi.org/10.2174/138527212803520173
DOI https://dx.doi.org/10.2174/138527212803520173 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
MicroRNAs as Potential Therapeutic Agents in the Treatment of Myocardial Infarction
Current Vascular Pharmacology Non-Viral Delivery of RNA Interference Targeting Cancer Cells in Cancer Gene Therapy
Current Gene Therapy Aloperine Induces Apoptosis by a Reactive Oxygen Species Activation Mechanism in Human Ovarian Cancer Cells
Protein & Peptide Letters Intracellular Bioinorganic Chemistry and Cross Talk Among Different -Omics
Current Topics in Medicinal Chemistry Hyaluronidase Inhibitors: A Biological and Therapeutic Perspective
Current Medicinal Chemistry A Review on Plasmodium falciparum-Protein Farnesyltransferase Inhibitors as Antimalarial Drug Targets
Current Drug Targets Synthesis and Anti-tumor Activities of Novel Phenyl Substituted Suberoylanilide Hydroxamic Acid Derivatives Against Human Cancer Cells
Medicinal Chemistry Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions
Current Drug Metabolism Optimization of CDTE Quantum Dots Synthesis Using Capillary Zone Electrophoresis
Current Nanoscience Histone Modifications as Molecular Targets in Nasopharyngeal Cancer
Current Medicinal Chemistry Pathway Analysis for Design of Promiscuous Drugs and Selective Drug Mixtures
Current Drug Discovery Technologies Photodynamic Therapy in Melanoma - Where do we Stand?
Current Medicinal Chemistry Subject Index To Volume 1
Recent Patents on Anti-Cancer Drug Discovery Diverse Mechanisms of AKT Pathway Activation in Human Malignancy
Current Cancer Drug Targets Recent Patents Reveal Microtubules as Persistent Promising Target for Novel Drug Development for Cancers
Recent Patents on Anti-Infective Drug Discovery New Molecular and Cellular Targets for Chemoprevention and Treatment of Skin Tumors by Plant Polyphenols: A Critical Review
Current Medicinal Chemistry Cyclooxygenase as a Target for Colorectal Cancer Chemoprevention
Current Drug Targets Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review
Current Medicinal Chemistry Using Nutrigenomics to Evaluate Apoptosis as a Preemptive Target in Cancer Prevention
Current Cancer Drug Targets Cell Cycle and Cancer: The G1 Restriction Point and the G1 / S Transition
Current Genomics