Lipid based Nanocarriers for Oral Delivery of Cancer Chemotherapeutics: An Insight in the Intestinal Lymphatic Transport

Javed      Ahmad; Kanchan      Kohli; Showkat R.      Mir; Saima      Amin

doi:10.2174/2210304x11303010006

Abstract

Mostly anticancer drugs are given as IV infusions, which result in hypertensive reactions due to formulation excipients. Their oral bioavailability is poor or variable due to high liver metabolism, poor aqueous solubility, high Pgp effluxing and macron size. To promote the oral drug delivery of these potential chemotherapeutics, intestinal lymphatic transport has been recognized as a promising route of drug delivery, especially for nanonized cytotoxic drugs because the spread of cancer is much early in lymphatics than the vascular system. A little research has been endeavored to deliver orally, the chemotherapeutics through lymphatic route owing to the complex mechanism involved in their complete absorption. This review will provide insight into the delivery of lipid based nanocarriers through lymphatic transport system for enhancing the oral bioavailability of anticancer moieties.

Keywords: Lipids, intestinal lumen, absorption, lymphatic, anticancer.

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