Active Methylene Compounds in the Synthesis of 3-substituted Isobenzofuranones, Isoindolinones and Related Compounds

Title:Active Methylene Compounds in the Synthesis of 3-substituted Isobenzofuranones, Isoindolinones and Related Compounds

Volume: 16 Issue: 19

Author(s): Antonia Di Mola, Laura Palombi and Antonio Massa

Affiliation:

Keywords: Heterocyclic compounds, Bioactive compounds, Active methylene compounds, Tandem reactions, Organocatalysis, Metal catalysts, Aldol reactions, Multi-component reactions, 1, 3-dicarbonyl, hydroxymethylation, formaldehyde

Abstract: Molecules containing 3-substituted isobenzofuranones and isoindolinones skeletons are found in important bioactive compounds and in a number of natural products. As a consequence several synthetic strategies, both asymmetric and non-asymmetric, have been developed. Thus, this review focuses on the main synthetic approaches to obtain these classes of compounds, analysing the common features, the scope and the limitations and at the same time giving particular emphasis to the role of active methylene compounds.

Cite this article as:

Di Mola Antonia, Palombi Laura and Massa Antonio, Active Methylene Compounds in the Synthesis of 3-substituted Isobenzofuranones, Isoindolinones and Related Compounds, Current Organic Chemistry 2012; 16 (19) . https://dx.doi.org/10.2174/138527212803520254