Novel Strategies for Hepatocellular Carcinoma Based on MMPs Science

Title:Novel Strategies for Hepatocellular Carcinoma Based on MMPs Science

Volume: 12 Issue: 7

Author(s): Isao Okazaki and Yutaka Inagaki

Affiliation:

Keywords: Hepatocellular carcinoma (HCC), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Alcoholic liver diseases, Non-alcoholic liver diseases, Bone marrow-derived stem cell, Matrix metalloproteinase (MMP), Tissue inhibitor of metalloproteinase (TIMP), Cancer invasion, Cancer metastasis, Cancer treatment, Anti-cancer agents, cancer stem cell.

Abstract: Hepatocellular carcinoma (HCC) is a cancer with extremely poor prognosis. This review discusses the pathological characteristics of multi-step hepatocarcinogenesis, tumor growth, invasion and metastasis, the expression of matrix metalloproteinases (MMPs) and their inhibitors via signal transduction in relation to dedifferentiation of hepatoma cells. It introduces the reports on anti-cancer agents in the field of MMP science, and finally describes novel strategies for the early stages of HCC in relation to cancer stem cells.

Cite this article as:

Okazaki Isao and Inagaki Yutaka, Novel Strategies for Hepatocellular Carcinoma Based on MMPs Science, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (7) . https://dx.doi.org/10.2174/187152012802650165