Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide

Wei      Sun; Jiyong      Wu; Jing      Li; Hao      Fang; Lupei      Du; Minyong      Li

doi:10.2174/092986712801323270

Abstract

Hydrogen peroxide (H2O2) has entrapped the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine since it is thought to be associated with various biological and pathological conditions. Fluorescent probes are the promising tools for the detection and understanding of the physiological roles of H2O2, considering that they are able to provide spatial and temporal information about target biomolecules in living cells. Nevertheless, the existent fluorescent probes have low selectivity and sensitivity on discerning H2O2. This review would like to demonstrate a comprehensive examination on the design, recognition, and performance of state-of-the-art boronate-based fluorogenic switch for the detection of H2O2, a field in which remarkable improvements have been accomplished over the last decade.

Keywords: Hydrogen peroxide, Fluorescent probes, Boronate, pathological conditions, biomolecules, boronate-based fluorogenic, Reactive oxygen species (ROS), byproducts, hydroxyl radical, dichlorodihydrofluorescein