Abstract
Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars compacta and the associated deficiency of the neurotransmitter dopamine in the striatum. Most cases of PD are of a sporadic nature whose cause is unknown, while mutations in several genes have been linked to genetic forms of PD (α-synuclein, Parkin, DJ-1, PINK1, and LRRK2). Epidemiological studies in humans, as well as molecular studies in toxin-induced (e.g. 6-hydroxydopamine (6-OHDA) and rotenone) and genetic animal models of PD show that mitochondrial dysfunction, especially Complex I, is a defect occurring early in the pathogenesis of both sporadic and familial PD. Mitochondrial dynamics (fission, fusion, migration) are important for neurotransmission, synaptic maintenance and neuronal survival.....
CNS & Neurological Disorders - Drug Targets
Title:Commentary
Volume: 11 Issue: 3
Author(s): Stephen D. Skaper
Affiliation:
Abstract: Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars compacta and the associated deficiency of the neurotransmitter dopamine in the striatum. Most cases of PD are of a sporadic nature whose cause is unknown, while mutations in several genes have been linked to genetic forms of PD (α-synuclein, Parkin, DJ-1, PINK1, and LRRK2). Epidemiological studies in humans, as well as molecular studies in toxin-induced (e.g. 6-hydroxydopamine (6-OHDA) and rotenone) and genetic animal models of PD show that mitochondrial dysfunction, especially Complex I, is a defect occurring early in the pathogenesis of both sporadic and familial PD. Mitochondrial dynamics (fission, fusion, migration) are important for neurotransmission, synaptic maintenance and neuronal survival.....
Export Options
About this article
Cite this article as:
D. Skaper Stephen, Commentary, CNS & Neurological Disorders - Drug Targets 2012; 11 (3) . https://dx.doi.org/10.2174/187152712800672391
DOI https://dx.doi.org/10.2174/187152712800672391 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies
Current Pharmaceutical Design Mechanisms of Bone Erosion in Chronic Gout: Lessons Learned from Other Erosive Arthropathies
Current Rheumatology Reviews Chemokines in Gastrointestinal Disorders
Current Drug Targets Neurophysiological Mechanisms Related to Pain Management in Bone Tumors
Current Neuropharmacology Promiscuous Biological Features of Newly Emerged SARS-CoV-2 Facilitate its Unrestrained Outbreak: An Update
Coronaviruses Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17
Anti-Cancer Agents in Medicinal Chemistry Opportunities and Challenges in Nano-structure Mediated Drug Delivery: Where Do We Stand?
Current Nanomedicine Oxidative Stress, Mitochondrial Dysfunction, and Stress Signaling in Alzheimers Disease
Current Alzheimer Research Virgin Olive Oil and Hypertension
Current Vascular Pharmacology Molecular Pharmacology of the Glycine Receptor Chloride Channel
Current Pharmaceutical Design Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma lucidum
Recent Patents on Inflammation & Allergy Drug Discovery C. elegans as a Genetic Model System to Identify Parkinson's Disease- Associated Therapeutic Targets
CNS & Neurological Disorders - Drug Targets [General Articles] Cannabinoids: Mechanisms and Therapeutic Applications in the CNS
Current Medicinal Chemistry Drug-Induced Liver Injury: Mechanisms, Types and Biomarkers
Current Medicinal Chemistry Update on the Slow Delayed Rectifier Potassium Current (IKs): Role in Modulating Cardiac Function
Current Medicinal Chemistry Anti-Oxidants in Parkinson’s Disease Therapy: A Critical Point of View
Current Neuropharmacology The Search for a Topical Dual Action Spermicide/Microbicide
Current Medicinal Chemistry Aneuploidy-Inducing Mutations in Mitotic Checkpoint Protein hMad1-Carboxi Terminal Domain Analyzed by SAR and Computational Mutagenesis
Current Proteomics Pharmacological Characteristics and Clinical Applications of K201
Current Clinical Pharmacology Protein Kinases as Drug Targets in Human and Animal Diseases
Current Enzyme Inhibition