Abstract
We designed a novel recombinant fusion protein r-NAP5-hirudin 12-residue-RGD with bi-functional inhibitory activities against platelet aggregation and thrombin. Our strategy may supply a potential multi-functional drug for the prevention and management of thrombosis.
Keywords: Thrombosis, Hirudin 12-residue, Thrombin, NAP5, Platelet aggregation, Recombinant fusion protein
Letters in Drug Design & Discovery
Title: A Novel Recombinant Fusion Protein Exhibited Inhibitory Activities on Platelet Aggregation and Thrombin
Volume: 7 Issue: 3
Author(s): Zongli Hu, Zhiping Zhao, Yan Liang, Yong Li and Guoping Chen
Affiliation:
Keywords: Thrombosis, Hirudin 12-residue, Thrombin, NAP5, Platelet aggregation, Recombinant fusion protein
Abstract: We designed a novel recombinant fusion protein r-NAP5-hirudin 12-residue-RGD with bi-functional inhibitory activities against platelet aggregation and thrombin. Our strategy may supply a potential multi-functional drug for the prevention and management of thrombosis.
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Cite this article as:
Hu Zongli, Zhao Zhiping, Liang Yan, Li Yong and Chen Guoping, A Novel Recombinant Fusion Protein Exhibited Inhibitory Activities on Platelet Aggregation and Thrombin, Letters in Drug Design & Discovery 2010; 7 (3) . https://dx.doi.org/10.2174/157018010790596605
DOI https://dx.doi.org/10.2174/157018010790596605 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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