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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

A Novel Recombinant Fusion Protein Exhibited Inhibitory Activities on Platelet Aggregation and Thrombin

Author(s): Zongli Hu, Zhiping Zhao, Yan Liang, Yong Li and Guoping Chen

Volume 7, Issue 3, 2010

Page: [182 - 187] Pages: 6

DOI: 10.2174/157018010790596605

Price: $65

Abstract

We designed a novel recombinant fusion protein r-NAP5-hirudin 12-residue-RGD with bi-functional inhibitory activities against platelet aggregation and thrombin. Our strategy may supply a potential multi-functional drug for the prevention and management of thrombosis.

Keywords: Thrombosis, Hirudin 12-residue, Thrombin, NAP5, Platelet aggregation, Recombinant fusion protein


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