Quantitative Structure-Activity Relationship Studies on Matrix Metalloproteinase Inhibitors: Hydroxamic Acid Analogs

Title: Quantitative Structure-Activity Relationship Studies on Matrix Metalloproteinase Inhibitors: Hydroxamic Acid Analogs

Volume: 2 Issue: 3

Author(s): S. P. Gupta and S. Kumaran

Affiliation:

Keywords: quantitative structure-activity relationship, matrix metalloproteinase inhibitors, Hydroxamic acid analogs

Abstract: A quantitative structure-activity relationship study has been conducted on two different series of acyclic hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The results suggest that in a few cases, the hydrophobic property of the molecules is the major governing factor. However, in some cases, the polarizability of the molecules is shown to be dominant. The two enzymes, MMP-9 and MMP-13, are shown to behave in a similar fashion with any group of inhibitors.

Cite this article as:

Gupta P. S. and Kumaran S., Quantitative Structure-Activity Relationship Studies on Matrix Metalloproteinase Inhibitors: Hydroxamic Acid Analogs, Medicinal Chemistry 2006; 2 (3) . https://dx.doi.org/10.2174/157340606776930790