Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

Title: Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

Volume: 7 Issue: 3

Author(s): Jing Li, Wenlong Huang, Huibin Zhang and Huiping Zhou

Affiliation:

Keywords: Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity

Abstract: The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.

Cite this article as:

Li Jing, Huang Wenlong, Zhang Huibin and Zhou Huiping, Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives, Letters in Drug Design & Discovery 2010; 7 (3) . https://dx.doi.org/10.2174/157018010790596614