Abstract
This review compiles the scientific basis to propose the pleiotrophin/receptor protein tyrosine phosphatase β/ζ signaling pathway as a new therapeutic target to prevent drug of abuse-induced toxicity. In addition, potential guidelines are provided for the development of new therapeutic compounds derived from that knowledge. This approach may be relevant since efficient therapeutic strategies are currently lacking in this field, even when drug-induced neurotoxicity seems to underlie the neurodegenerative disorders diagnosed in drug addicts.
Keywords: Neurodegeneration, cocaine, Parkinson's disease, drug discovery, pleiotrophin, midkine, RPTPβ/ζ, drug development
Mini-Reviews in Medicinal Chemistry
Title: Targeting the Pleiotrophin/Receptor Protein Tyrosine Phosphatase β /ζ Signaling Pathway to Limit Neurotoxicity Induced by Drug Abuse
Volume: 9 Issue: 4
Author(s): Gonzalo Herradon, Laura Ezquerra, Esther Gramage and Luis F. Alguacil
Affiliation:
Keywords: Neurodegeneration, cocaine, Parkinson's disease, drug discovery, pleiotrophin, midkine, RPTPβ/ζ, drug development
Abstract: This review compiles the scientific basis to propose the pleiotrophin/receptor protein tyrosine phosphatase β/ζ signaling pathway as a new therapeutic target to prevent drug of abuse-induced toxicity. In addition, potential guidelines are provided for the development of new therapeutic compounds derived from that knowledge. This approach may be relevant since efficient therapeutic strategies are currently lacking in this field, even when drug-induced neurotoxicity seems to underlie the neurodegenerative disorders diagnosed in drug addicts.
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Herradon Gonzalo, Ezquerra Laura, Gramage Esther and Alguacil F. Luis, Targeting the Pleiotrophin/Receptor Protein Tyrosine Phosphatase β /ζ Signaling Pathway to Limit Neurotoxicity Induced by Drug Abuse, Mini-Reviews in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/138955709787847895
DOI https://dx.doi.org/10.2174/138955709787847895 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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