Abstract
Mangosteen (Garcinia mangostana L.; Clusiaceae) is a popular botanical dietary supplement in the United States, where it is used principally as an antioxidant. It is referred to as the “queen of fruits” in Thailand, a country of origin. The major secondary metabolites of mangosteen, the xanthones, exhibit a variety of biological activities including antibacterial, antifungal, antiinflammatory, antioxidant, antiplasmodial, cytotoxic, and potential cancer chemopreventive activities. Moreover, some of the xanthones from mangosteen have been found to influence specific enzyme activities, such as aromatase, HIV-1 protease, inhibitor κB kinase, quinone reductase, sphingomyelinase, topoisomerase and several protein kinases, and they also modulate histamine H1 and 5-hydroxytryptamine2A receptor binding. Several synthetic procedures for active xanthones and their analogs have been conducted to obtain a better insight into structure-activity relationships for this compound class. This short review deals with progress made in the structural characterization of the chemical constituents of mangosteen, as well as the biological activity of pure constituents of this species and synthetic methods for the mangosteen xanthones.
Keywords: Xanthones, Mangosteen, Garcinia mangostana, Biological Effects, antioxidant, botanical dietary, antiinflammatory, antibacterial, antiplasmodial, HIV-1 protease
Mini-Reviews in Organic Chemistry
Title: Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement
Volume: 5 Issue: 4
Author(s): Young-Won Chin and A. Douglas Kinghorn
Affiliation:
Keywords: Xanthones, Mangosteen, Garcinia mangostana, Biological Effects, antioxidant, botanical dietary, antiinflammatory, antibacterial, antiplasmodial, HIV-1 protease
Abstract: Mangosteen (Garcinia mangostana L.; Clusiaceae) is a popular botanical dietary supplement in the United States, where it is used principally as an antioxidant. It is referred to as the “queen of fruits” in Thailand, a country of origin. The major secondary metabolites of mangosteen, the xanthones, exhibit a variety of biological activities including antibacterial, antifungal, antiinflammatory, antioxidant, antiplasmodial, cytotoxic, and potential cancer chemopreventive activities. Moreover, some of the xanthones from mangosteen have been found to influence specific enzyme activities, such as aromatase, HIV-1 protease, inhibitor κB kinase, quinone reductase, sphingomyelinase, topoisomerase and several protein kinases, and they also modulate histamine H1 and 5-hydroxytryptamine2A receptor binding. Several synthetic procedures for active xanthones and their analogs have been conducted to obtain a better insight into structure-activity relationships for this compound class. This short review deals with progress made in the structural characterization of the chemical constituents of mangosteen, as well as the biological activity of pure constituents of this species and synthetic methods for the mangosteen xanthones.
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Cite this article as:
Chin Young-Won and Kinghorn Douglas A., Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement, Mini-Reviews in Organic Chemistry 2008; 5 (4) . https://dx.doi.org/10.2174/157019308786242223
DOI https://dx.doi.org/10.2174/157019308786242223 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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