Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity

Title: Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity

Volume: 8 Issue: 9

Author(s): S. Agatonovic-Kustrin and J. V. Turner

Affiliation:

Keywords: Computer aided drug design, molecular modeling, structure-activity relationship, hormones, drug design, structure, QSAR, phytoestrogens

Abstract: This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.

Cite this article as:

Agatonovic-Kustrin S. and Turner V. J., Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132747