Abstract
Background: Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER) which is crucial to the correct embryological development of the heart in mice. Altered expression levels in the adult were correlated with several cardiac pathologies such as cardiac hypertrophy and dilated cardiomyopathy.
Aim: In this review, we aim to describe the role of calreticulin in the embryological development of the heart in mice and to clarify the relationship between the different cardiac pathologies and altered expression levels of calreticulin in the adult heart.
Conclusion: There is an ER crucial to embryogenesis in cardiomyocytes besides SR. Certain stimuli may induce reactivation of the transcription pattern present during embryogenesis, leading to overexpression of calreticulin in the heart, altering numerous signaling pathways and subsequently inducing pathology. Normalization of these transcriptional disorders holds promise in the treatment of multiple cardiac diseases.
Keywords: Calreticulin, endoplasmic reticulum, fetal lethality, hypertrophy, ischemia-reperfusion, dilated cardiomyopathy, arrhythmia, heart block.
Current Molecular Medicine
Title:Calreticulin in the Heart: From Embryological Development to Cardiac Pathology.
Volume: 16 Issue: 1
Author(s): D. Martinho-Dias, A. Leite-Moreira and P. Castro-Chaves
Affiliation:
Keywords: Calreticulin, endoplasmic reticulum, fetal lethality, hypertrophy, ischemia-reperfusion, dilated cardiomyopathy, arrhythmia, heart block.
Abstract: Background: Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER) which is crucial to the correct embryological development of the heart in mice. Altered expression levels in the adult were correlated with several cardiac pathologies such as cardiac hypertrophy and dilated cardiomyopathy.
Aim: In this review, we aim to describe the role of calreticulin in the embryological development of the heart in mice and to clarify the relationship between the different cardiac pathologies and altered expression levels of calreticulin in the adult heart.
Conclusion: There is an ER crucial to embryogenesis in cardiomyocytes besides SR. Certain stimuli may induce reactivation of the transcription pattern present during embryogenesis, leading to overexpression of calreticulin in the heart, altering numerous signaling pathways and subsequently inducing pathology. Normalization of these transcriptional disorders holds promise in the treatment of multiple cardiac diseases.
Export Options
About this article
Cite this article as:
Martinho-Dias D., Leite-Moreira A. and Castro-Chaves P., Calreticulin in the Heart: From Embryological Development to Cardiac Pathology., Current Molecular Medicine 2016; 16 (1) . https://dx.doi.org/10.2174/1566524016666151222142816
DOI https://dx.doi.org/10.2174/1566524016666151222142816 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Eisenmenger Syndrome: Recent Advances in Pharmacotherapy
Cardiovascular & Hematological Agents in Medicinal Chemistry High-Density Lipoprotein-Raising Strategies: Update 2010
Current Pharmaceutical Design Update on the Evaluation and Management of Brief Resolved Unexplained Events (Previously Apparent Life-Threatening Events)
Reviews on Recent Clinical Trials Patent Selections
Recent Patents on Cardiovascular Drug Discovery Genetics and Heart Failure: A Concise Guide for the Clinician
Current Cardiology Reviews Meet the Editorial Board:
Current Drug Targets Leptin and the Ob-Receptor as Anti-Obesity Target: Recent In Silico Advances in the Comprehension of the Protein-Protein Interaction and Rational Drug Design of Anti- Obesity Lead Compounds
Current Pharmaceutical Design Electrochemical-Based Biosensors: New Diagnosis Platforms for Cardiovascular Disease
Current Medicinal Chemistry Cardiac Regeneration: Stem Cells and Beyond
Current Medicinal Chemistry Regulation of Intracellular Cardiomyocyte Calcium Stores by Peptides: A New Approach to Cardiac Protection
Current Medicinal Chemistry Bone Marrow Mesenchymal Stem Cells: Agents of Immunomodulation and Neuroprotection
Current Stem Cell Research & Therapy Inflammatory Mechanisms in Atherosclerosis: The Impact of Matrix Metalloproteinases
Current Topics in Medicinal Chemistry Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage
Current Molecular Pharmacology Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy
Current Pharmaceutical Design Antiviral Drugs that Target Cellular Proteins May Play Major Roles in Combating HIV Resistance
Current Pharmaceutical Design Conformations and Assembly of Amyloid Oligomers by Electrospray Ionisation - Ion Mobility Spectrometry - Mass Spectrometry
Current Analytical Chemistry G Protein-Coupled Receptors – Potential Roles in Clinical Pharmacology
Cardiovascular & Hematological Agents in Medicinal Chemistry Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders
Current Pharmaceutical Design Cellular Membranes and Lipid-Binding Domains as Attractive Targets for Drug Development
Current Drug Targets Diagnostic Value of HLA Typing in Pathogenesis of Cardiomyopathy
Cardiovascular & Hematological Disorders-Drug Targets