Abstract
Human longevity is influenced by both inherited and environmental factors. Alterations in gene function that are related to inherited genetic mutations and polymorphisms can explain some features of aging and age-related diseases. However, in addition to inherited genetic factors, aging is influenced by the gradual accumulation of molecular alterations after birth. Epigenetic changes can influence gene function during aging without inherited and acquired DNA sequence alterations. In particular, promoter DNA methylation changes and associated gene silencing are epigenetic changes that are prominent in some cells and age-related diseases. Here, we review genetic approaches to understand aging, and discuss the potential role of epigenetic mechanisms in human aging and age-related diseases.
Keywords: DNA methylation, epigenetics, genetics, Aging
Current Chemical Biology
Title: Aging and DNA Methylation
Volume: 3 Issue: 1
Author(s): Jei Kim, Jee-Yeon Kim and Jean-Pierre J. Issa
Affiliation:
Keywords: DNA methylation, epigenetics, genetics, Aging
Abstract: Human longevity is influenced by both inherited and environmental factors. Alterations in gene function that are related to inherited genetic mutations and polymorphisms can explain some features of aging and age-related diseases. However, in addition to inherited genetic factors, aging is influenced by the gradual accumulation of molecular alterations after birth. Epigenetic changes can influence gene function during aging without inherited and acquired DNA sequence alterations. In particular, promoter DNA methylation changes and associated gene silencing are epigenetic changes that are prominent in some cells and age-related diseases. Here, we review genetic approaches to understand aging, and discuss the potential role of epigenetic mechanisms in human aging and age-related diseases.
Export Options
About this article
Cite this article as:
Kim Jei, Kim Jee-Yeon and Issa J. Jean-Pierre, Aging and DNA Methylation, Current Chemical Biology 2009; 3 (1) . https://dx.doi.org/10.2174/2212796810903010001
DOI https://dx.doi.org/10.2174/2212796810903010001 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Sex Steroid Hormones, Cardiovascular Diseases and The Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Development of Immunopharmacotherapy Against Drugs of Abuse
Current Drug Discovery Technologies Triglycerides and Vascular Risk: Insights from Epidemiological Data and Interventional Studies
Current Drug Targets Asymmetric Dimethylarginine (ADMA): A Promising Biomarker for Cardiovascular Disease?
Current Topics in Medicinal Chemistry Interleukin-6 In Rheumatoid Arthritis - From The Laboratory To The Bedside
Current Pharmaceutical Design The Extracellular Matrix of Blood Vessels
Current Pharmaceutical Design Beta-Blockers and Nitrates: Pharmacotherapy and Indications
Cardiovascular & Hematological Agents in Medicinal Chemistry Inflammatory Related Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Targets
Current Pharmaceutical Design Bioresorbable Scaffolds for Atheroregression: Understanding of Transient Scaffolding
Current Cardiology Reviews Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery
Current Gene Therapy Integrating Pharmacogenetics for Assessment of Herb-Drug Interactions: Has the Time Come?
Current Pharmacogenomics and Personalized Medicine Long-Acting Antipsychotic Medications
Current Drug Targets Atherosclerotic Coronary Heart Disease Epidemiology, Classification and Management
Cardiovascular & Hematological Disorders-Drug Targets Short- and Long-Term Survival of Nonsurgical Intensive Care Patients and its Relation to Diagnosis, Severity of Disease, Age and Comorbidities
Current Aging Science Fibrates in the Chemical Action of Daunorubicin
Current Cancer Drug Targets Stacking Regression Algorithms to Predict PM<sub>2.5</sub> in the Smart City Using Internet of Things
Recent Advances in Computer Science and Communications Drug Treatment of Metabolic Syndrome
Current Clinical Pharmacology Impact of Prone Position on Myocardial Perfusion SPECT Interpretation in Women with Suspected Coronary Disease
Current Medical Imaging Renal Ischemia: How Commonly Does it Cause Renal Failure?
Current Hypertension Reviews Calcium Sensitizers in Cardiac Surgery: Who, When, How and Why?
Current Vascular Pharmacology