Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease

Nahum      Mendez-Sanchez; Hector      Baptista-Gonzalez; Norberto   C.   Chavez-Tapia; Daniel      Zamora-Valdes; Misael      Uribe

doi:10.2174/138955708783498087

Abstract

Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.

Keywords: Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease

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