APP-Based Neuroprotective Strategies

Title: APP-Based Neuroprotective Strategies

Volume: 4 Issue: 5

Author(s): Dale E. Bredesen and Shahrooz Rabizadeh

Affiliation:

Keywords: amyloid precursor protein interactors, Alzheimers disease, degenerating neuron, misfolded proteins, caspase

Abstract: While much of the focus on Alzheimers disease therapeutics has been directed at beta-amyloid peptide or at cholinergic synaptic transmission, recent data suggest that targeting signal transduction by the amyloid precursor protein (APP) itself may be an alternative approach with significant potential [1]. Here we discuss the possibility that APPmediated signal transduction, downstream from amyloid-beta peptide production itself, may be an appropriate therapeutic target in Alzheimers disease.

Cite this article as:

Bredesen E. Dale and Rabizadeh Shahrooz, APP-Based Neuroprotective Strategies, Current Alzheimer Research 2007; 4 (5) . https://dx.doi.org/10.2174/156720507783018253