Abstract
Background: Oxidative stress and amyloid deposition are tightly interconnected pathological features of Alzheimer disease. In this respect, both amyloid production and aggregation may be stimulated by oxidative stress and also the increase of pathogenic β-amyloid and its aggregated form lead to oxidative stress progression. Therefore, the search for potential drugs with both antioxidant and antiaggregation properties are of great interest.
Methods: In this study, we described the stereospecific synthesis of alkaloid securinine aminoderivatives. Results: We showed that the newly synthesized compounds possess antioxidant and metal-chelating properties. Indeed, we report that one compound has inhibitory effects towards μ-amyloid aggregation. Conclusion: Based on these results, aminoderivatives of securinine scaffold are promising compounds for development of new drugs for the treatment of neurodegenerative diseases.Keywords: Alkaloids, antioxidant, lipid peroxidation, neurodegenerative diseases, neuroprotection, securinine, μ-amyloid.
Graphical Abstract
CNS & Neurological Disorders - Drug Targets
Title:Securinine Derivatives as Potential Anti-amyloid Therapeutic Approach
Volume: 16 Issue: 3
Author(s): Margarita E. Neganova, Sergei G. Klochkov, Ludmila N. Petrova, Elena F. Shevtsova, Svetlana V. Afanasieva, Ekaterina S. Chudinova, Vladimir P. Fisenko, Sergei O. Bachurin, George E. Barreto and Gjumrakch Aliev*
Affiliation:
- ,United States
Keywords: Alkaloids, antioxidant, lipid peroxidation, neurodegenerative diseases, neuroprotection, securinine, μ-amyloid.
Abstract: Background: Oxidative stress and amyloid deposition are tightly interconnected pathological features of Alzheimer disease. In this respect, both amyloid production and aggregation may be stimulated by oxidative stress and also the increase of pathogenic β-amyloid and its aggregated form lead to oxidative stress progression. Therefore, the search for potential drugs with both antioxidant and antiaggregation properties are of great interest.
Methods: In this study, we described the stereospecific synthesis of alkaloid securinine aminoderivatives. Results: We showed that the newly synthesized compounds possess antioxidant and metal-chelating properties. Indeed, we report that one compound has inhibitory effects towards μ-amyloid aggregation. Conclusion: Based on these results, aminoderivatives of securinine scaffold are promising compounds for development of new drugs for the treatment of neurodegenerative diseases.Export Options
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Cite this article as:
Neganova E. Margarita, Klochkov G. Sergei, Petrova N. Ludmila, Shevtsova F. Elena, Afanasieva V. Svetlana, Chudinova S. Ekaterina, Fisenko P. Vladimir, Bachurin O. Sergei, Barreto E. George and Aliev Gjumrakch*, Securinine Derivatives as Potential Anti-amyloid Therapeutic Approach, CNS & Neurological Disorders - Drug Targets 2017; 16 (3) . https://dx.doi.org/10.2174/1871527315666161107090525
DOI https://dx.doi.org/10.2174/1871527315666161107090525 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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