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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Author(s): Ahmed Kamal, S. Kaleem Ahmed, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, B. Siddhardha, U. S.N. Murty, Arnab China and V. Nagaraja

Volume 4, Issue 8, 2007

Page: [550 - 556] Pages: 7

DOI: 10.2174/157018007782794563

Price: $65

Abstract

A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin.

Keywords: Benzothiadiazines, Benzothiazoles, Antibacterial activity, DNA gyrase inhibition


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