Abstract
Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.
Keywords: membrane proteins crystallography
Mini-Reviews in Medicinal Chemistry
Title: Crystallography of Membrane Proteins, Major Targets in Drug Design
Volume: 3 Issue: 5
Author(s): J. Wouters
Affiliation:
Keywords: membrane proteins crystallography
Abstract: Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.
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Cite this article as:
Wouters J., Crystallography of Membrane Proteins, Major Targets in Drug Design, Mini-Reviews in Medicinal Chemistry 2003; 3 (5) . https://dx.doi.org/10.2174/1389557033488015
DOI https://dx.doi.org/10.2174/1389557033488015 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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