Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors

Title: Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors

Volume: 3 Issue: 7

Author(s): Todd A. Houston and Joanne T. Blanchfield

Affiliation:

Keywords: glycosidase inhibitors, glucosidase, mannosidase, galactosidase, sialidase, salacinol, cyclophellitol

Abstract: Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.

Cite this article as:

Houston A. Todd and Blanchfield T. Joanne, Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487827