DNA Microarray-Based Gene Expression Profiling in Cancer: Aiding Cancer Diagnosis, Assessing Prognosis and Predicting Response to Therapy

Title: DNA Microarray-Based Gene Expression Profiling in Cancer: Aiding Cancer Diagnosis, Assessing Prognosis and Predicting Response to Therapy

Volume: 3 Issue: 4

Author(s): Michael J. Duffy, Zoe D. Kelly, Aedín C. Culhane, Sallyann L. O'Brien and William M. Gallagher

Affiliation:

Keywords: DNA microarrays, cancer, tumor markers, diagnosis, prognosis and prediction

Abstract: A DNA microarray is a solid support such as a glass slide, silicon chip or nylon membrane on which DNA molecules are attached at precise locations. Using DNA microarrays, the expression of tens of thousands of genes in a biological sample can be detected in one experiment. Emerging data suggests that the use of DNA microarrays can aid the differentiation of tumors with similar morphological appearance, predict patient outcome independently of conventional prognostic factors and select for response or resistance to specific anti-cancer therapies. DNA microarray technology thus has the potential to supplement standard diagnostic procedures in oncology and permit a more individualized approach to patient management. Prior to clinical application, however, this methodology must be simplified, standardized, evaluated in external quality assessment schemes and made available at relatively low costs. Most importantly, the preliminary, but promising, early findings must be validated by high-level evidence studies, such as large prospective randomized trials or meta-analyses.

Cite this article as:

Duffy J. Michael, Kelly D. Zoe, Culhane C. Aedín, O'Brien L. Sallyann and Gallagher M. William, DNA Microarray-Based Gene Expression Profiling in Cancer: Aiding Cancer Diagnosis, Assessing Prognosis and Predicting Response to Therapy, Current Pharmacogenomics 2005; 3 (4) . https://dx.doi.org/10.2174/157016005774913158