Abstract
The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.
Keywords: pacap, neurodegeneration, neuroprotection, parkinson, huntington
Letters in Drug Design & Discovery
Title: Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases
Volume: 2 Issue: 4
Author(s): D. Reglodi, A. Tamas and A. Somogyvari-Vigh
Affiliation:
Keywords: pacap, neurodegeneration, neuroprotection, parkinson, huntington
Abstract: The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.
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Reglodi D., Tamas A. and Somogyvari-Vigh A., Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038440
DOI https://dx.doi.org/10.2174/1570180054038440 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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