Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia

Title:Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia

Volume: 18 Issue: 5

Author(s): Oscar Teijido *, Juan Carlos Carril and Ramón Cacabelos

Affiliation:

• EuroEspes Biomedical Research Center, Institute of Medical Science and Genomic Medicine, 15165-Bergondo, Corunna, Spain; Genomic Medicine, Camilo José Cela University, 28692-Madrid,Spain

Keywords: Dementia, Alzheimer's disease, Hypertension, Metabolic syndrome, APOE, Vascular risk.

Abstract: Introduction: Cardiovascular and neurodegenerative disorders are among the major causes of mortality in the developed countries. Population studies evaluate the genetic risk, i.e. the probability of an individual carrying a specific disease-associated polymorphism. Identification of risk polymorphisms is essential for an accurate diagnosis or prognosis of a number of pathologies.

Aims: The aim of this study was to characterize the influence of risk polymorphisms associated with lipid metabolism, hypertension, thrombosis, and dementia, in a large population of Spanish individuals affected by a variety of brain and vascular disorders as well as metabolic syndrome.

Material & Method: We performed a cross-sectional study on 4415 individuals from a widespread regional distribution in Spain (48.15% males and 51.85% females), with mental, neurodegenerative, cerebrovascular, and metabolic disorders. We evaluated polymorphisms in 20 genes involved in obesity, vascular and cardiovascular risk, and dementia in our population and compared it with representative Spanish and European populations. Risk polymorphisms in ACE, AGT(235), IL6(573), PSEN1, and APOE (specially the APOE-ε4 allele) are representative of our population as compared to the reference data of Spanish and European individuals.

Conclusion: The significantly higher distribution of risk polymorphisms in PSEN1 and APOE-ε4 is characteristic of a representative number of patients with Alzheimer’s disease; whereas polymorphisms in ACE, AGT(235), and IL6(573), are most probably related with the high number of patients with metabolic syndrome or cerebrovascular damage.

Cite this article as:

Teijido Oscar *, Carril Carlos Juan and Cacabelos Ramón , Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia, Current Genomics 2017; 18 (5) . https://dx.doi.org/10.2174/1389202918666170608093833

DOI https://dx.doi.org/10.2174/1389202918666170608093833	Print ISSN 1389-2029
Publisher Name Bentham Science Publisher	Online ISSN 1875-5488