Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity

Title: Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity

Volume: 2 Issue: 4

Author(s): Mayur C. Yerigeri, Satish Kumar Murari, Salahuddin Mohammed, Shanta Kumar Sugur Math, Kuntebommanahalli N. Thimmaiah and Bannikuppe Sannanaik Vishwanath

Affiliation:

Keywords: phospholipase, anti-inflammatory, azetidin-one derivatives

Abstract: The title compounds have been synthesized and tested for structure activity relationship for Phospholipase A2 (PLA2) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA2 enzyme inhibitory activity of azetidin-2-one derivatives and in vivo anti-inflammatory activity studies using mice are highlighted. The results show that some azetidin-2-one derivatives are very good PLA2 inhibitors and can also be used as antiinflammatory drugs.

Cite this article as:

Yerigeri C. Mayur, Murari Kumar Satish, Mohammed Salahuddin, Math Kumar Sugur Shanta, Thimmaiah N. Kuntebommanahalli and Vishwanath Sannanaik Bannikuppe, Synthesis of Azetidin-2-One Derivatives as Inhibitor of Secretory Phospholipase A2 with Anti-Inflammatory Activity, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038404

DOI https://dx.doi.org/10.2174/1570180054038404	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X