5-HT7 Receptor Ligands: Recent Developments and Potential Therapeutic Applications

Title: 5-HT7 Receptor Ligands: Recent Developments and Potential Therapeutic Applications

Volume: 7 Issue: 9

Author(s): Valeria Pittala, Loredana Salerno, Maria Modica, Maria Angela Siracusa and Giuseppe Romeo

Affiliation:

Keywords: Serotonin, serotonin receptor subtypes, 5-HT7Rs, 5-HT7 ligands, G protein-coupled receptors, agonists, antagonists

Abstract: The 5-HT7 receptors (5-HT7Rs) are the most recent classified members of the serotonin family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since their discovery, they have been the subject of intense research due to their widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to discuss the literature concerning recent advances on 5-HT7Rs and their ligands.

Cite this article as:

Pittala Valeria, Salerno Loredana, Modica Maria, Siracusa Angela Maria and Romeo Giuseppe, 5-HT7 Receptor Ligands: Recent Developments and Potential Therapeutic Applications, Mini-Reviews in Medicinal Chemistry 2007; 7 (9) . https://dx.doi.org/10.2174/138955707781662663