NR2B Selective NMDA Antagonists: The Evolution of the Ifenprodil-Type Pharmacophore

Title: NR2B Selective NMDA Antagonists: The Evolution of the Ifenprodil-Type Pharmacophore

Volume: 6 Issue: 7

Author(s): Istvan Borza and Gyorgy Domany

Affiliation:

Keywords: Ifenprodil, NR2B subunit, pharmacophore, side activities, piperidines

Abstract: The quest for NR2B subtype selective NMDA antagonists started almost twenty years ago. The structure of ifenprodil, the prototype of this group of compounds, inspired many medicinal chemists in several research units. Different approaches led to the identification of the pharmacophore and several distinct classes of compounds containing this pharmacophore. From these studies a few drug candidates emerged and clinical trials proved the viability of the concept. This article attempted to follow the evolution from ifenprodil, a multiple ligand, to selective NR2B antagonists.

Cite this article as:

Borza Istvan and Domany Gyorgy, NR2B Selective NMDA Antagonists: The Evolution of the Ifenprodil-Type Pharmacophore, Current Topics in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/156802606776894456