Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

Title: Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

Volume: 18 Issue: 9

Author(s): J. C. Borges and C. H.I. Ramos

Affiliation:

Keywords: Analytical ultracentrifugation, protein folding, Mycobacterium tuberculosis, protein structure-function, anti-tuberculosis agents, high centrifugal force, hydrodynamic parameters, sedimentation, colloids, macromolecules

Abstract: The interest in analytical ultracentrifugation (AUC) to analyze protein structural parameters and interactions has increased in the past decades as a result of several developments on new generation instrumentation and data analysis tools. In this article, we review AUC principles and applications to study proteins, emphasizing molecular targets of Mycobacterium tuberculosis.

Cite this article as:

C. Borges J. and H.I. Ramos C., Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation, Current Medicinal Chemistry 2011; 18 (9) . https://dx.doi.org/10.2174/092986711795029537