No Association Between GRM3 and Japanese Methamphetamine- Induced Psychosis

Title: No Association Between GRM3 and Japanese Methamphetamine- Induced Psychosis

Volume: 9 Issue: 1

Author(s): Takenori Okumura, Nakao Iwata, Norio Ozaki, Masaomi Iyo, Ichiro Sora, > Uchimura, Mitsuhiko Yamada, Hiroshi Ujike, Toshiya Inada, Tomoko Tsunoka, Tomo Okochi, Kunihiro Kawashima, Yoko Kinoshita, Yoshio Yamanouchi, Tsuyoshi Kitajima, Masashi Ikeda and Taro Kishi

Affiliation:

Keywords: GRM3, Methamphetamine-Induced Psychosis, case-control study, schizophrenia, 3 receptor (mGluR3), METH-INDUCED PSYCHOSIS, MOOD DISORDER, psychotic disorder

Abstract: Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamineinduced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls). Methods: We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). Results: We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis. Conclusion: Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine- induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.

Cite this article as:

Okumura Takenori, Iwata Nakao, Ozaki Norio, Iyo Masaomi, Sora Ichiro, Uchimura >, Yamada Mitsuhiko, Ujike Hiroshi, Inada Toshiya, Tsunoka Tomoko, Okochi Tomo, Kawashima Kunihiro, Kinoshita Yoko, Yamanouchi Yoshio, Kitajima Tsuyoshi, Ikeda Masashi and Kishi Taro, No Association Between GRM3 and Japanese Methamphetamine- Induced Psychosis, Current Neuropharmacology 2011; 9 (1) . https://dx.doi.org/10.2174/157015911795017001