Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

Title: Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

Volume: 9 Issue: 1

Author(s): Yasuhisa Fukuo, Nakao Iwata, Hiroshi Ujike, Norio Ozaki, Ichiro Sora, Masaomi Iyo, Naohisa Uchimura, Mitsuhiko Yamada, Toshiya Inada, Takenori Okumura, Tomoko Tsunoka, Kunihiro Kawashima, Yoko Kinoshita, Tsuyoshi Kitajima, Masashi Ikeda, Taro Kishi and Tomo Okochi

Affiliation:

Keywords: Methamphetamine-induced psychosis, neuronal nitric oxide synthase 1 gene (NOS1), case-control association study, case-control association, serotonin, mesolimbic system, schizophrenia, neurotransmitters, psychotic disorders, comorbid diagnosis, anxiety disorder, mood disorder, METH-induced psychosis, NOS1

Abstract: The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Cite this article as:

Fukuo Yasuhisa, Iwata Nakao, Ujike Hiroshi, Ozaki Norio, Sora Ichiro, Iyo Masaomi, Uchimura Naohisa, Yamada Mitsuhiko, Inada Toshiya, Okumura Takenori, Tsunoka Tomoko, Kawashima Kunihiro, Kinoshita Yoko, Kitajima Tsuyoshi, Ikeda Masashi, Kishi Taro and Okochi Tomo, Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese, Current Neuropharmacology 2011; 9 (1) . https://dx.doi.org/10.2174/157015911795017308