Abstract
The [2+2+1]-cycloaddition of an alkyne, an alkene and carbon monoxide known as Pauson-Khand reaction is a powerful way to install two new functional groups and a cycle into a molecule. The great potential of this reaction has thus far been underestimated in the synthesis of pharmacologically active compounds.
Keywords: Pauson-Khand reaction, drug discovery, Diversity-oriented synthesis, target-oriented synthesis
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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