Abstract
Since a couple of decades, respiratory ailments have emerged as a significant public health issue. Numerous primitive civilizations acknowledged the need to relieve the inflamed airways and nasal passages oxidants are a persistent danger to the lungs since they can be produced either intracellularly by metabolic processes (such as mitochondrial electron transfer during respiration or during phagocyte activation) or from another source such as tobacco smoking or air pollutants. It is likely to be advantageous to target oxidative stress with antioxidants or increase endogenous antioxidant levels in the treatment of COPD, asthma, and COVID-19. In trials on both human beings and animals, the administration of small antioxidants via the intratracheal, oral, and vascular routes exhibited only minimal therapeutic potential against short- and long-term oxidative stress. Lipids, proteins, and nucleic acids all respond to oxygen in quick and practical ways. For the ROS (reactive oxygen species) system to run properly, it requires adequate oxidation-reducing components, like vitamins and antioxidants intake. Numerous nutrients, including vitamins such as vitamin A, vitamin B etc., minerals (magnesium, zinc, and iron), flavonoids, and fatty acids, have prominent functions in reducing the likelihood of viral diseases and chronic lung disorders. In this review, the applications of antioxidants in the prevention of respiratory diseases are discussed along with some reported nutraceuticals being used in respiratory disease and patents. The applications of antioxidants in preventing and managing respiratory diseases are discussed in this review, shedding light on the importance of ongoing research in this field. Nutraceuticals, which combine the benefits of nutrition and pharmaceuticals, are also explored as potential solutions for respiratory health.
[1]
Chan Y, Allam VSR, Paudel KR, et al. Nutraceuticals: Unlocking newer paradigms in the mitigation of inflammatory lung diseases. Crit Rev Food Sci Nutr 2021; 6: 1-31.
[PMID: 34613853]
[PMID: 34613853]
[2]
Rai RR, Phadke MS. Plasma oxidant-antioxidant status in different respiratory disorders. Indian J Clin Biochem 2006; 21(2): 161-4.
[http://dx.doi.org/10.1007/BF02912934] [PMID: 23105636]
[http://dx.doi.org/10.1007/BF02912934] [PMID: 23105636]
[3]
Bland JS. Phytonutrition, phytotherapy, and phytopharmacology. Altern Ther Health Med 1996; 2(6): 73-6.
[PMID: 8942046]
[PMID: 8942046]
[4]
Berger MM, Shenkin A. Vitamins and trace elements: Practical aspects of supplementation. Nutrition 2006; 22(9): 952-5.
[http://dx.doi.org/10.1016/j.nut.2006.06.004] [PMID: 16928476]
[http://dx.doi.org/10.1016/j.nut.2006.06.004] [PMID: 16928476]
[5]
Bagchi D. Nutraceuticals and functional foods regulations in the United States and around the world. Toxicology 2006; 221(1): 1-3.
[http://dx.doi.org/10.1016/j.tox.2006.01.001]
[http://dx.doi.org/10.1016/j.tox.2006.01.001]
[6]
Available from:https://www.sciencedirect.com/science/article/pii/B9780128021477000061 (Accessed on: 9th Sep, 2022).
[7]
Lakshmi S, Shafreen RMB, Priya A, Shunmugiah KP. Ethnomedicines of Indian origin for combating COVID-19 infection by hampering the viral replication: using structure-based drug discovery approach. J Biomol Struct Dyn 2020; 1-16.
[PMID: 32573351]
[PMID: 32573351]
[8]
Boukhatem MN, Setzer WN. Aromatic herbs, medicinal plant-derived essential oils, and phytochemical extracts as potential therapies for coronaviruses: future perspectives. Plants 2020; 9(6): 800.
[http://dx.doi.org/10.3390/plants9060800] [PMID: 32604842]
[http://dx.doi.org/10.3390/plants9060800] [PMID: 32604842]
[9]
Ryu YB, Park SJ, Kim YM, et al. SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii. Bioorg Med Chem Lett 2010; 20(6): 1873-6.
[http://dx.doi.org/10.1016/j.bmcl.2010.01.152] [PMID: 20167482]
[http://dx.doi.org/10.1016/j.bmcl.2010.01.152] [PMID: 20167482]
[10]
Sudo N, Yu XN, Aiba Y, et al. An oral introduction of intestinal bacteria prevents the development of a long-term Th2-skewed immunological memory induced by neonatal antibiotic treatment in mice. Clin Exp Allergy 2002; 32(7): 1112-6.
[http://dx.doi.org/10.1046/j.1365-2222.2002.01430.x] [PMID: 12100062]
[http://dx.doi.org/10.1046/j.1365-2222.2002.01430.x] [PMID: 12100062]
[11]
Ho T, Wu S, Chen J, Li C, Hsiang C. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res 2007; 74(2): 92-101.
[http://dx.doi.org/10.1016/j.antiviral.2006.04.014] [PMID: 16730806]
[http://dx.doi.org/10.1016/j.antiviral.2006.04.014] [PMID: 16730806]
[12]
Kaliora AC, Dedoussis GVZ, Schmidt H. Dietary antioxidants in preventing atherogenesis. Atherosclerosis 2006; 187(1): 1-17.
[http://dx.doi.org/10.1016/j.atherosclerosis.2005.11.001] [PMID: 16313912]
[http://dx.doi.org/10.1016/j.atherosclerosis.2005.11.001] [PMID: 16313912]
[13]
Available from:https://www.researchgate.net/figure/Common-exogenous-antioxidants-and-examples-of-their-dietary-sources_tbl1_225056880 (Accessed on: 9th Sep 2022).
[14]
Ciencewicki J, Trivedi S, Kleeberger SR. Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol 2008; 122(3): 456-68.
[http://dx.doi.org/10.1016/j.jaci.2008.08.004] [PMID: 18774381]
[http://dx.doi.org/10.1016/j.jaci.2008.08.004] [PMID: 18774381]
[15]
Thimmulappa RK, Chattopadhyay I, Rajasekaran S. Oxidative
Stress Mechanisms in the Pathogenesis of Environmental Lung
Diseases. In: Chakraborti S, Parinandi N, Ghosh R, Ganguly N,
Chakraborti T, Eds. Oxidative Stress in Lung Diseases. Singapore:
Springer 2020.
[http://dx.doi.org/10.1007/978-981-32-9366-3_5]
[http://dx.doi.org/10.1007/978-981-32-9366-3_5]
[16]
Devine JF. Chronic obstructive pulmonary disease: An overview. Am Health Drug Benefits 2008; 1(7): 34-42.
[PMID: 25126252]
[PMID: 25126252]
[17]
Alvarado A, Arce I. Antioxidants in respiratory diseases: Basic science research and therapeutic alternatives. Clin Res Trials 2016; 3(1)
[http://dx.doi.org/10.15761/CRT.1000163]
[http://dx.doi.org/10.15761/CRT.1000163]
[18]
Cross C, O’Neil CA, Reznick AZ, et al. Cigarette smoke oxidation of human plasma constituents. Ann N Y Acad Sci 1993; 686(1): 72-89.
[http://dx.doi.org/10.1111/j.1749-6632.1993.tb39157.x] [PMID: 8512263]
[http://dx.doi.org/10.1111/j.1749-6632.1993.tb39157.x] [PMID: 8512263]
[19]
Sargeant LA, Jaeckel A, Wareham NJ. Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. Eur Respir J 2000; 16(3): 397-403.
[http://dx.doi.org/10.1034/j.1399-3003.2000.016003397.x] [PMID: 11028650]
[http://dx.doi.org/10.1034/j.1399-3003.2000.016003397.x] [PMID: 11028650]
[20]
Cantin AM, North SL, Hubbard RC, Crystal RG. Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol 1987; 63(1): 152-7.
[http://dx.doi.org/10.1152/jappl.1987.63.1.152] [PMID: 3040659]
[http://dx.doi.org/10.1152/jappl.1987.63.1.152] [PMID: 3040659]
[21]
Poole P, Black PN. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: Systematic review. BMJ 2001; 322(7297): 1271-4.
[http://dx.doi.org/10.1136/bmj.322.7297.1271] [PMID: 11375228]
[http://dx.doi.org/10.1136/bmj.322.7297.1271] [PMID: 11375228]
[22]
Rahman I. Antioxidant therapies in COPD. Int J Chron Obstruct Pulmon Dis 2006; 1(1): 15-29.
[http://dx.doi.org/10.2147/copd.2006.1.1.15] [PMID: 18046899]
[http://dx.doi.org/10.2147/copd.2006.1.1.15] [PMID: 18046899]
[23]
Hu G, Cassano PA. Antioxidant nutrients and pulmonary function: The Third National Health and Nutrition Examination Survey (NHANES III). Am J Epidemiol 2000; 151(10): 975-81.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a010141] [PMID: 10853636]
[http://dx.doi.org/10.1093/oxfordjournals.aje.a010141] [PMID: 10853636]
[24]
Keranis E, Makris D, Rodopoulou P, et al. Impact of dietary shift to higher-antioxidant foods in COPD: A randomised trial. Eur Respir J 2010; 36(4): 774-80.
[http://dx.doi.org/10.1183/09031936.00113809] [PMID: 20150206]
[http://dx.doi.org/10.1183/09031936.00113809] [PMID: 20150206]
[25]
Sies H. Oxidative stress: Oxidants and antioxidants. Exp Physiol 1997; 82(2): 291-5.
[http://dx.doi.org/10.1113/expphysiol.1997.sp004024] [PMID: 9129943]
[http://dx.doi.org/10.1113/expphysiol.1997.sp004024] [PMID: 9129943]
[26]
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010; 4(8): 118-26.
[http://dx.doi.org/10.4103/0973-7847.70902] [PMID: 22228951]
[http://dx.doi.org/10.4103/0973-7847.70902] [PMID: 22228951]
[27]
Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG. Manipulating antioxidant intake in asthma: A randomized controlled trial. Am J Clin Nutr 2012; 96(3): 534-43.
[http://dx.doi.org/10.3945/ajcn.111.032623] [PMID: 22854412]
[http://dx.doi.org/10.3945/ajcn.111.032623] [PMID: 22854412]
[28]
Dillard CJ, German JB. Phytochemicals: Nutraceuticals and human health. J Sci Food Agric 2000; 80(12): 1744-56.
[http://dx.doi.org/10.1002/1097-0010(20000915)80:12<1744::AID-JSFA725>3.0.CO;2-W]
[http://dx.doi.org/10.1002/1097-0010(20000915)80:12<1744::AID-JSFA725>3.0.CO;2-W]
[29]
Available from:https://www.who.int/news-room/fact-sheets/detail/tuberculosis (Accessed on: 25th August 2023).
[30]
Cegielski JP, McMurray DN. The relationship between malnutrition and tuberculosis: Evidence from studies in humans and experimental animals. Int J Tuberc Lung Dis 2004; 8(3): 286-98.
[PMID: 15139466]
[PMID: 15139466]
[31]
Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007; 51(4): 301-23.
[http://dx.doi.org/10.1159/000107673] [PMID: 17726308]
[http://dx.doi.org/10.1159/000107673] [PMID: 17726308]
[32]
Soh AZ, Chee CBE, Wang YT, Yuan JM, Koh WP. Dietary intake of antioxidant vitamins and carotenoids and risk of developing active tuberculosis in a prospective population-based cohort study. Am J Epidemiol 2017; 186(4): 491-500.
[http://dx.doi.org/10.1093/aje/kwx132] [PMID: 28520939]
[http://dx.doi.org/10.1093/aje/kwx132] [PMID: 28520939]
[33]
Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614960/ (Accessed on: 10th September 2022).
[34]
Wheelwright M, Kim EW, Inkeles MS, et al. All-trans retinoic acid-triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2. J Immunol 2014; 192(5): 2280-90.
[http://dx.doi.org/10.4049/jimmunol.1301686] [PMID: 24501203]
[http://dx.doi.org/10.4049/jimmunol.1301686] [PMID: 24501203]
[35]
Gouri B, Shankar P. Level of antioxidant vitamins in children suffering from pneumonia. Curr Pediatric Res 2011; 15(1): 11-3.
[36]
Kuti BP, Akinwumi AI, Kuti DK, Amoo KO. Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children. Egypt J Bronchol 2020; 14(1): 29.
[http://dx.doi.org/10.1186/s43168-020-00029-8]
[http://dx.doi.org/10.1186/s43168-020-00029-8]
[37]
Soto ME, Guarner-Lans V, Soria-Castro E, Manzano Pech L, Pérez-Torres I. Is antioxidant therapy a useful complementary measure for COVID-19 treatment? An algorithm for its application. Medicina 2020; 56(8): 386.
[http://dx.doi.org/10.3390/medicina56080386] [PMID: 32752010]
[http://dx.doi.org/10.3390/medicina56080386] [PMID: 32752010]
[38]
Available from:https://clinicaltrials.gov/ct2/show/NCT04323228 (Accessed on: 14th September 2022)
[39]
Aisa-Alvarez A, Soto ME, Guarner-Lans V, et al. Usefulness of antioxidants as adjuvant therapy for septic shock: A randomized clinical trial. Medicina 2020; 56(11): 619.
[http://dx.doi.org/10.3390/medicina56110619] [PMID: 33213070]
[http://dx.doi.org/10.3390/medicina56110619] [PMID: 33213070]
[40]
Available from:https://virologyj.biomedcentral.com/articles/10. 1186/s12985-022-01814-1 (Accessed on: 25th August 2023).
[41]
Available from:https://www.sciencedirect.com/science/article/pii/S200103702100060X?via%3Dihub (Accessed on: 14th September 2022).
[42]
Available from:https://foodsafetyhelpline.com/nutraceuticals-challenges-fast-growing-sector-india/ (Accessed on: 10th September 2022).
[43]
Siddiqui RA, Moghadasian MH. Nutraceuticals and nutrition supplements: Challenges and opportunities. Nutrients 2020; 12(6): 1593.
[http://dx.doi.org/10.3390/nu12061593] [PMID: 32485839]
[http://dx.doi.org/10.3390/nu12061593] [PMID: 32485839]
[44]
Dhami N, Mishra AD. Phytochemical variation: How to resolve the quality controversies of herbal medicinal products? J Herb Med 2015; 5(2): 118-27.
[http://dx.doi.org/10.1016/j.hermed.2015.04.002]
[http://dx.doi.org/10.1016/j.hermed.2015.04.002]
[45]
Hermans N, Cos P, Maes L, De Bruyne T. Challenges and pitfalls in antioxidant research. Current Medicinal Chemistry 2007; 14(4): 417-30.
[46]
Barnes PJ, Stockley RA. COPD: current therapeutic interventions and future approaches. Eur Respir J 2005; 25(6): 1084-106.
[http://dx.doi.org/10.1183/09031936.05.00139104] [PMID: 15929966]
[http://dx.doi.org/10.1183/09031936.05.00139104] [PMID: 15929966]
[47]
Kelly FJ. Vitamins and respiratory disease: Antioxidant micronutrients in pulmonary health and disease. Proc Nutr Soc 2005; 64(4): 510-26.
[http://dx.doi.org/10.1079/PNS2005457] [PMID: 16313695]
[http://dx.doi.org/10.1079/PNS2005457] [PMID: 16313695]
[48]
Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases. Front Physiol 2020; 11: 694.
[http://dx.doi.org/10.3389/fphys.2020.00694] [PMID: 32714204]
[http://dx.doi.org/10.3389/fphys.2020.00694] [PMID: 32714204]
[49]
Nyunoya T, March TH, Tesfaigzi Y, Seagrave J. Antioxidant diet protects against emphysema, but increases mortality in cigarette smoke-exposed mice. COPD 2011; 8(5): 362-8.
[http://dx.doi.org/10.3109/15412555.2011.600361] [PMID: 21834692]
[http://dx.doi.org/10.3109/15412555.2011.600361] [PMID: 21834692]
[50]
Barnes PJ. Oxidative stress in chronic obstructive pulmonary disease. Antioxidants 2022; 11(5): 965.
[http://dx.doi.org/10.3390/antiox11050965] [PMID: 35624831]
[http://dx.doi.org/10.3390/antiox11050965] [PMID: 35624831]
[51]
Tong H. Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity. Biochim Biophys Acta, Gen Subj 2016; 1860(12): 2891-8.
[http://dx.doi.org/10.1016/j.bbagen.2016.05.014] [PMID: 27189803]
[http://dx.doi.org/10.1016/j.bbagen.2016.05.014] [PMID: 27189803]
[52]
Cook-Mills JM, Averill SH, Lajiness JD. Asthma, allergy and vitamin E: Current and future perspectives. Free Radic Biol Med 2022; 179: 388-402.
[http://dx.doi.org/10.1016/j.freeradbiomed.2021.10.037] [PMID: 34785320]
[http://dx.doi.org/10.1016/j.freeradbiomed.2021.10.037] [PMID: 34785320]
[53]
Name JJ, Souza ACR, Vasconcelos AR, Prado PS, Pereira CPM. Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 with a focus on physical tissue barrier integrity. Front Nutr 2020; 7: 606398.
[http://dx.doi.org/10.3389/fnut.2020.606398] [PMID: 33365326]
[http://dx.doi.org/10.3389/fnut.2020.606398] [PMID: 33365326]
[54]
Bae M, Kim H. The role of vitamin C, Vitamin D, and selenium in immune system against COVID-19. Molecules 2020; 25(22): 5346.
[http://dx.doi.org/10.3390/molecules25225346] [PMID: 33207753]
[http://dx.doi.org/10.3390/molecules25225346] [PMID: 33207753]
[55]
Zhang Y, Ding S, Li C, Wang Y, Chen Z, Wang Z. Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis. Exp Ther Med 2017; 14(4): 2863-8.
[http://dx.doi.org/10.3892/etm.2017.4891] [PMID: 28928799]
[http://dx.doi.org/10.3892/etm.2017.4891] [PMID: 28928799]
[56]
Day BJ. Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal 2008; 10(2): 355-70.
[http://dx.doi.org/10.1089/ars.2007.1916] [PMID: 17999627]
[http://dx.doi.org/10.1089/ars.2007.1916] [PMID: 17999627]
[57]
Dhanawat GS. Rhinitis, sinusitis and ocular disease – 2100. New approach to treat allergic rhinitis with Vitamin E, cod liver oil and Vitamin C with use of nasal steroidal spray. World Allergy Organ J 2013; 6 (Suppl. 1): P175.
[http://dx.doi.org/10.1186/1939-4551-6-S1-P175]
[http://dx.doi.org/10.1186/1939-4551-6-S1-P175]
[58]
Perronova N, Fedoreev SA, Vasilyeva EA. Antioxidants composition suitable for oral administration in therapy of inflammatory process in lungs. RU2684783C1, 2018.
[59]
Trif ML, Darhilberg CJ, Bobishway JG. Antioxidant composition of echinochrome, ascorbic acid and αtocopherol for treating inflammatory processes in lungs. MISHCHENKO, 2019.
[60]
Trif ML, Darhilberg CJ, Bobishway JG. Phyto complexes exhibiting multiple synergistic antioxidant activities useful in food, dietary supplements, cosmetic preparations and pharmaceutical preparations. KR20180021674A, 2016.
