Abstract
Patients with symptomatic severe aortic stenosis (AS) benefit from aortic valve replacement surgery, but the management of patients with asymptomatic severe AS is more controversial. While cholesterol and angiotensin have been linked to AS progression, we should await the results of ongoing randomized trials before medical therapy to lower cholesterol or inhibit angiotensin can be recommended to limit disease progression. Clinical factors, echocardiographic parameters, valve morphology, exercise stress testing results, and cardiac biomarkers may be useful in identifying patients who will have early development of symptoms during follow-up and require closer monitoring. The risks associated with aortic valve replacement outweigh the benefits in the majority of patients with asymptomatic severe AS.
Keywords: Aortic valve stenosis, symptoms, management, surgery, exercise testing, brain natriuretic peptide
Current Cardiology Reviews
Title: Management of Asymptomatic Severe Aortic Stenosis
Volume: 5 Issue: 1
Author(s): Robert L. Stewart and Kwan L. Chan
Affiliation:
Keywords: Aortic valve stenosis, symptoms, management, surgery, exercise testing, brain natriuretic peptide
Abstract: Patients with symptomatic severe aortic stenosis (AS) benefit from aortic valve replacement surgery, but the management of patients with asymptomatic severe AS is more controversial. While cholesterol and angiotensin have been linked to AS progression, we should await the results of ongoing randomized trials before medical therapy to lower cholesterol or inhibit angiotensin can be recommended to limit disease progression. Clinical factors, echocardiographic parameters, valve morphology, exercise stress testing results, and cardiac biomarkers may be useful in identifying patients who will have early development of symptoms during follow-up and require closer monitoring. The risks associated with aortic valve replacement outweigh the benefits in the majority of patients with asymptomatic severe AS.
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Cite this article as:
Stewart L. Robert and Chan L. Kwan, Management of Asymptomatic Severe Aortic Stenosis, Current Cardiology Reviews 2009; 5 (1) . https://dx.doi.org/10.2174/157340309787048103
DOI https://dx.doi.org/10.2174/157340309787048103 |
Print ISSN 1573-403X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6557 |
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