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Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Review Article

A Review of Lipid and Protein Oxidation During Digestion

Author(s): Mohammadali Torbati, Solmaz Abedinzadeh*, Sima Khezri, Fataneh Hashempour-Baltork and Sodeif Azadmard-Damirchi

Volume 19, Issue 5, 2023

Published on: 10 March, 2023

Page: [549 - 563] Pages: 15

DOI: 10.2174/1573401319666230111162630

Price: $65

Abstract

Lipid and protein oxidation are important reactions in food systems and can degrade food quality and decrease consumer acceptability. Several factors affect the rate and severity of these undesirable reactions in food products. However, lipid and protein oxidations can occur in the digestive system, which is much more complex than in simple food systems. Under digestive conditions, food matrix and composition are the major factors affecting lipid and protein oxidations in the body. Lipid and protein oxidation in food matrixes or the digestive system, as well as product absorption rate, can have serious consequences for human health. This review aimed to present recent information and discussion on the effects of digestion conditions and natural and synthetic antioxidants on lipid and protein oxidation.

Graphical Abstract

[1]
Hashempour-Baltork F, Torbati M, Azadmard-Damirchi S, Savage GP. Vegetable oil blending: A review of physicochemical, nutritional and health effects. Trends Food Sci Technol 2016; 57: 52-8.
[http://dx.doi.org/10.1016/j.tifs.2016.09.007]
[2]
Socrier L, Quéro A, Verdu M, et al. Flax phenolic compounds as inhibitors of lipid oxidation: Elucidation of their mechanisms of action. Food Chem 2019; 274: 651-8.
[PMID: 30372990]
[3]
Nieva-Echevarría B, Goicoechea E, Guillén MD. Food lipid oxidation under gastrointestinal digestion conditions: A review. Crit Rev Food Sci Nutr 2018; 60: 1-18.
[PMID: 30596262]
[4]
Yang J, Xiong YL. Comparative time-course of lipid and myofibrillar protein oxidation in different biphasic systems under hydroxyl radical stress. Food Chem 2018; 243: 231-8.
[http://dx.doi.org/10.1016/j.foodchem.2017.09.146] [PMID: 29146333]
[5]
Silva AMN, Marçal SL, Vitorino R, Domingues MRM, Domingues P. Characterization of in vitro protein oxidation using mass spectrometry: A time course study of oxidized alpha-amylase. Arch Biochem Biophys 2013; 530(1): 23-31.
[http://dx.doi.org/10.1016/j.abb.2012.12.010] [PMID: 23246785]
[6]
Mariutti LRB, Bragagnolo N. Influence of salt on lipid oxidation in meat and seafood products: A review. Food Res Int 2017; 94: 90-100.
[http://dx.doi.org/10.1016/j.foodres.2017.02.003] [PMID: 28290372]
[7]
Mazaheri Y, Torbati M, Azadmard-Damirchi S, Savage GP. Effect of roasting and microwave pre-treatments of Nigella sativa L. seeds on lipase activity and the quality of the oil. Food Chem 2019; 274: 480-6.
[http://dx.doi.org/10.1016/j.foodchem.2018.09.001] [PMID: 30372968]
[8]
Ferreira VC, et al. Role of protein oxidation in the nutritional loss and texture changes in ready-to-eat chicken patties. IJFST 2018; 53(6): 1518-26.
[9]
Van Hecke T, Van Camp J, De Smet S. Oxidation during digestion of meat: Interactions with the diet and Helicobacter pylori gastritis, and implications on human health. Compr Rev Food Sci Food Saf 2017; 16(2): 214-33.
[http://dx.doi.org/10.1111/1541-4337.12248] [PMID: 33371537]
[10]
Zabel M, Nackenoff A, Kirsch WM, Harrison FE, Perry G, Schrag M. Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer’s disease brain: A meta-analysis in human pathological specimens. Free Radic Biol Med 2018; 115: 351-60.
[http://dx.doi.org/10.1016/j.freeradbiomed.2017.12.016] [PMID: 29253591]
[11]
Tullberg C, Vegarud G, Undeland I. Oxidation of marine oils during in vitro gastrointestinal digestion with human digestive fluids-Role of oil origin, added tocopherols and lipolytic activity. Food Chem 2019; 270: 527-37.
[12]
Kanner J, Lapidot T. The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants. Free Radic Biol Med 2001; 31(11): 1388-95.
[http://dx.doi.org/10.1016/S0891-5849(01)00718-3] [PMID: 11728810]
[13]
Goicoechea E, Brandon EFA, Blokland MH, Guillén MD. Fate in digestion in vitro of several food components, including some toxic compounds coming from omega-3 and omega-6 lipids. Food Chem Toxicol 2011; 49(1): 115-24.
[http://dx.doi.org/10.1016/j.fct.2010.10.005] [PMID: 20937346]
[14]
Steppeler C, Haugen JE, Rødbotten R, Kirkhus B. Formation of malondialdehyde, 4-hydroxynonenal, and 4-hydroxyhexenal during in vitro digestion of cooked beef, pork, chicken, and salmon. J Agric Food Chem 2016; 64(2): 487-96.
[http://dx.doi.org/10.1021/acs.jafc.5b04201] [PMID: 26654171]
[15]
Muttakin S, Moxon TE, Gouseti O. In vivo, in vitro, and in silico studies of the GI tract Interdisciplinary approaches to food digestion. Springer 2019; pp. 29-67.
[http://dx.doi.org/10.1007/978-3-030-03901-1_3]
[16]
Larsson K, Cavonius L, Alminger M, Undeland I. Oxidation of cod liver oil during gastrointestinal in vitro digestion. J Agric Food Chem 2012; 60(30): 7556-64.
[http://dx.doi.org/10.1021/jf301444x] [PMID: 22746365]
[17]
Gobert M, Rémond D, Loonis M, Buffière C, Santé-Lhoutellier V, Dufour C. Fruits, vegetables and their polyphenols protect dietary lipids from oxidation during gastric digestion. Food Funct 2014; 5(9): 2166-74.
[http://dx.doi.org/10.1039/C4FO00269E] [PMID: 25029433]
[18]
Hashempour-Baltork F, Torbati M, Azadmard-Damirchi S, Peter Savage G. Chemical, rheological and nutritional characteristics of sesame and olive oils blended with linseed oil. Adv Pharm Bull 2018; 8(1): 107-13.
[http://dx.doi.org/10.15171/apb.2018.013] [PMID: 29670845]
[19]
Nieva-Echevarría B, Goicoechea E, Guillén MD. Behaviour of non-oxidized and oxidized flaxseed oils, as models of omega-3 rich lipids, during in vitro digestion. Occurrence of epoxidation reactions. Food Res Int 2017; 97: 104-15.
[http://dx.doi.org/10.1016/j.foodres.2017.03.047] [PMID: 28578030]
[20]
Goicoechea E, Van Twillert K, Duits M, et al. Use of an in vitro digestion model to study the bioaccessibility of 4-hydroxy-2-nonenal and related aldehydes present in oxidized oils rich in omega-6 acyl groups. J Agric Food Chem 2008; 56(18): 8475-83.
[http://dx.doi.org/10.1021/jf801212k] [PMID: 18729379]
[21]
Csala M, Kardon T, Legeza B, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta Mol Basis Dis 2015; 1852(5): 826-38.
[http://dx.doi.org/10.1016/j.bbadis.2015.01.015] [PMID: 25643868]
[22]
Guillén MD, Goicoechea E. Toxic oxygenated α,β-unsaturated aldehydes and their study in foods: A review. Crit Rev Food Sci Nutr 2008; 48(2): 119-36.
[http://dx.doi.org/10.1080/10408390601177613] [PMID: 18274968]
[23]
Hashempour-Baltork F, Torbati M, Azadmard-Damirchi S, Savage GP. Quality properties of sesame and olive oils incorporated with flaxseed oil. Adv Pharm Bull 2017; 7(1): 97-101.
[http://dx.doi.org/10.15171/apb.2017.012] [PMID: 28507942]
[24]
Hooper C, De Souto Barreto P, Pahor M, Weiner M, Vellas B. The relationship of omega 3 polyunsaturated fatty acids in red blood cell membranes with cognitive function and brain structure: A review focussed on Alzheimer’s disease. J Prev Alzheimers Dis 2018; 5(1): 78-84.
[PMID: 29405237]
[25]
Guéraud F, Taché S, Steghens JP, et al. Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free Radic Biol Med 2015; 83: 192-200.
[http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.023] [PMID: 25744414]
[26]
Dasilva G, Pazos M, García-Egido E, et al. Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: Lipidomic biomarkers of oxidative stress and inflammation. J Nutr Biochem 2015; 26(11): 1385-92.
[http://dx.doi.org/10.1016/j.jnutbio.2015.07.007] [PMID: 26320676]
[27]
Dasilva G, Boller M, Medina I, Storch J. Relative levels of dietary EPA and DHA impact gastric oxidation and essential fatty acid uptake. J Nutr Biochem 2018; 55: 68-75.
[http://dx.doi.org/10.1016/j.jnutbio.2017.11.007] [PMID: 29413491]
[28]
Van Hecke T, Goethals S, Vossen E, De Smet S. Long-chain n-3 PUFA content and n-6/n-3 PUFA ratio in mammal, poultry, and fish muscles largely explain differential protein and lipid oxidation profiles following in vitro gastrointestinal digestion. Mol Nutr Food Res 2019; 63(22): 1900404.
[http://dx.doi.org/10.1002/mnfr.201900404] [PMID: 31483096]
[29]
Awada M, Soulage CO, Meynier A, et al. Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: Role of intestinal absorption of 4-HHE and reactivity in intestinal cells. J Lipid Res 2012; 53(10): 2069-80.
[http://dx.doi.org/10.1194/jlr.M026179] [PMID: 22865918]
[30]
Kristinova V, Storrø I, Rustad T. Influence of human gastric juice on oxidation of marine lipids – in vitro study. Food Chem 2013; 141(4): 3859-71.
[http://dx.doi.org/10.1016/j.foodchem.2013.06.011] [PMID: 23993559]
[31]
Tao L. Oxidation of polyunsaturated fatty acids and its impact on food quality and human health. Adv Food Technol Nutr Sci Open J 2015; 1: 135-42.
[http://dx.doi.org/10.17140/AFTNSOJ-1-123]
[32]
Elmadfa I, Kornsteiner M. Dietary fat intake-a global perspective. Ann Nutr Metab 2009; 54: 8-14.
[http://dx.doi.org/10.1159/000220822] [PMID: 19641345]
[33]
Zhang W, Xiao S, Ahn DU. Protein oxidation: Basic principles and implications for meat quality. Crit Rev Food Sci Nutr 2013; 53(11): 1191-201.
[http://dx.doi.org/10.1080/10408398.2011.577540] [PMID: 24007423]
[34]
Hematyar N, Rustad T, Sampels S, Kastrup DT. Relationship between lipid and protein oxidation in fish. Aquacult Res 2019; 50(5): 1393-403.
[http://dx.doi.org/10.1111/are.14012]
[35]
Rysman T, Van Hecke T, Van Poucke C, De Smet S, Van Royen G. Protein oxidation and proteolysis during storage and in vitro digestion of pork and beef patties. Food Chem 2016; 209: 177-84.
[http://dx.doi.org/10.1016/j.foodchem.2016.04.027] [PMID: 27173550]
[36]
Hu L, Ren S, Shen Q, Ye X, Chen J, Ling J. Protein oxidation and proteolysis during roasting and in vitro digestion of fish (Acipenser gueldenstaedtii). J Sci Food Agric 2018; 98(14): 5344-51.
[http://dx.doi.org/10.1002/jsfa.9075] [PMID: 29656426]
[37]
Van Hecke T, Vanden Bussche J, Vanhaecke L, Vossen E, De Smet S. The effect of nitrite-curing of chicken, pork and beef on oxidation and noc-specific DNA adduct formation during in vitro digestion, in: 59th International Congress of Meat Science and Technology. Izmir, Turkey. 2013.
[38]
Van Hecke T, Basso V, De Smet S. Lipid and protein oxidation during in vitro gastrointestinal digestion of pork under Helicobacter pylori gastritis conditions. J Agric Food Chem 2018; 66(49): 13000-10.
[http://dx.doi.org/10.1021/acs.jafc.8b04335] [PMID: 30411892]
[39]
Lavado G, Higuero N, León-Camacho M, Cava R. Formation of lipid and protein oxidation products during in vitro gastrointestinal digestion of dry-cured loins with different contents of nitrate/nitrite added. Foods 2021; 10(8): 1748.
[http://dx.doi.org/10.3390/foods10081748] [PMID: 34441526]
[40]
Zdanowska-Sąsiadek Ż, et al. Lipid-and protein oxidation during storage and in vitro gastrointestinal digestion of ostrich, beef and chicken jerky snacks. Anim Sci Pap Rep 2022; 40(3): 305-16.
[41]
Horbańczuk OK, et al. Lipid and protein oxidation in ostrich meat under various packaging types during refrigerated storage and in vitro gastrointestinal digestion Anim Sci Pap Rep 2021; 39(3)
[42]
Eckl PM, Bresgen N. Genotoxicity of lipid oxidation compounds. Free Radic Biol Med 2017; 111: 244-52.
[http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.002] [PMID: 28167130]
[43]
Vieira SA, Zhang G, Decker EA. Biological implications of lipid oxidation products. J Am Oil Chem Soc 2017; 94(3): 339-51.
[http://dx.doi.org/10.1007/s11746-017-2958-2]
[44]
Leonarduzzi G, Sottero B, Poli G. Oxidized products of cholesterol: Dietary and metabolic origin, and proatherosclerotic effects (review). J Nutr Biochem 2002; 13(12): 700-10.
[http://dx.doi.org/10.1016/S0955-2863(02)00222-X] [PMID: 12550054]
[45]
Kanner J. Dietary advanced lipid oxidation endproducts are risk factors to human health. Mol Nutr Food Res 2007; 51(9): 1094-101.
[PMID: 17854006]
[46]
Nieva-Echevarría B, Goicoechea E, Manzanos MJ, Guillén MD. Fishin vitro digestion: Influence of fish salting on the extent of lipolysis, oxidation, and other reactions. J Agric Food Chem 2017; 65(4): 879-91.
[http://dx.doi.org/10.1021/acs.jafc.6b04334] [PMID: 28052192]
[47]
Nugroho PA. Oxidation profile of meat digestion in vivo and in vitro. In: Ghent University 2017.
[48]
Van Hecke T, Vanden Bussche J, Vanhaecke L, Vossen E, Van Camp J, De Smet S. Nitrite curing of chicken, pork, and beef inhibits oxidation but does not affect N-nitroso compound (NOC)-specific DNA adduct formation during in vitro digestion. J Agric Food Chem 2014; 62(8): 1980-8.
[http://dx.doi.org/10.1021/jf4057583] [PMID: 24499368]
[49]
Van Hecke T, Vossen E, Hemeryck LY, Vanden Bussche J, Vanhaecke L, De Smet S. Increased oxidative and nitrosative reactions during digestion could contribute to the association between well-done red meat consumption and colorectal cancer. Food Chem 2015; 187: 29-36.
[http://dx.doi.org/10.1016/j.foodchem.2015.04.029] [PMID: 25976994]
[50]
Van Hecke T. Formation of oxidation products and N-nitroso-compounds during gastrointestinal digestion of fresh and processed meat. Ghent University 2016.
[51]
Tullberg C, Vegarud G, Undeland I. Oxidation of marine oils during in vitro gastrointestinal digestion with human digestive fluids – Role of oil origin, added tocopherols and lipolytic activity. Food Chem 2019; 270: 527-37.
[http://dx.doi.org/10.1016/j.foodchem.2018.07.049] [PMID: 30174082]
[52]
Tullberg C, Larsson K, Carlsson NG, et al. Formation of reactive aldehydes (MDA, HHE, HNE) during the digestion of cod liver oil: Comparison of human and porcine in vitro digestion models. Food Funct 2016; 7(3): 1401-12.
[http://dx.doi.org/10.1039/C5FO01332A] [PMID: 26838473]
[53]
Lapidot T, Granit R, Kanner J. Lipid hydroperoxidase activity of myoglobin and phenolic antioxidants in simulated gastric fluid. J Agric Food Chem 2005; 53(9): 3391-6.
[http://dx.doi.org/10.1021/jf040400w] [PMID: 15853377]
[54]
Lapidot T, Granit R, Kanner J. Lipid peroxidation by “free” iron ions and myoglobin as affected by dietary antioxidants in simulated gastric fluids. J Agric Food Chem 2005; 53(9): 3383-90.
[http://dx.doi.org/10.1021/jf040402g] [PMID: 15853376]
[55]
Hur SJ, Lee SY, Lee SJ. Effect of biopolymer encapsulation on the digestibility of lipid and cholesterol oxidation products in beef during in vitro human digestion. Food Chem 2015; 166: 254-60.
[http://dx.doi.org/10.1016/j.foodchem.2014.06.009] [PMID: 25053053]
[56]
Mohanan A, Nickerson MT, Ghosh S. Oxidative stability of flaxseed oil: Effect of hydrophilic, hydrophobic and intermediate polarity antioxidants. Food Chem 2018; 266: 524-33.
[http://dx.doi.org/10.1016/j.foodchem.2018.05.117] [PMID: 30381221]
[57]
Tabee E, Azadmard-Damirchi S, Jägerstad M, Dutta PC. Effects of α‐tocopherol on oxidative stability and phytosterol oxidation during heating in some regular and high-oleic vegetable oils. J Am Oil Chem Soc 2008; 85(9): 857-67.
[http://dx.doi.org/10.1007/s11746-008-1274-2]
[58]
Kenmogne-Domguia HB, Moisan S, Viau M, Genot C, Meynier A. The initial characteristics of marine oil emulsions and the composition of the media inflect lipid oxidation during in vitro gastrointestinal digestion. Food Chem 2014; 152: 146-54.
[http://dx.doi.org/10.1016/j.foodchem.2013.11.096] [PMID: 24444919]
[59]
Carocho M, Ferreira ICFR. A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 2013; 51: 15-25.
[http://dx.doi.org/10.1016/j.fct.2012.09.021] [PMID: 23017782]
[60]
Davis C, Bryan J, Hodgson J, Murphy K. Definition of the Mediterranean diet; a literature review. Nutrients 2015; 7(11): 9139-53.
[http://dx.doi.org/10.3390/nu7115459] [PMID: 26556369]
[61]
Lorrain B, Dangles O, Genot C, Dufour C. Chemical modeling of heme-induced lipid oxidation in gastric conditions and inhibition by dietary polyphenols. J Agric Food Chem 2010; 58(1): 676-83.
[http://dx.doi.org/10.1021/jf903054e] [PMID: 19911829]
[62]
Tesoriere L, Butera D, Gentile C, Livrea MA. Bioactive components of caper (Capparis spinosa L.) from Sicily and antioxidant effects in a red meat simulated gastric digestion. J Agric Food Chem 2007; 55(21): 8465-71.
[http://dx.doi.org/10.1021/jf0714113] [PMID: 17887802]
[63]
Dimitrios B. Sources of natural phenolic antioxidants. Trends Food Sci Technol 2006; 17(9): 505-12.
[http://dx.doi.org/10.1016/j.tifs.2006.04.004]
[64]
Martini S, Cavalchi M, Conte A, Tagliazucchi D. The paradoxical effect of extra-virgin olive oil on oxidative phenomena during in vitro co-digestion with meat. Food Res Int 2018; 109: 82-90.
[http://dx.doi.org/10.1016/j.foodres.2018.04.031] [PMID: 29803495]
[65]
Nieva-Echevarría B, Goicoechea E, Guillén MD. Oxidative stability of extra-virgin olive oil enriched or not with lycopene. Importance of the initial quality of the oil for its performance during in vitro gastrointestinal digestion. Food Res Int 2020; 130: 108987.
[http://dx.doi.org/10.1016/j.foodres.2020.108987] [PMID: 32156407]
[66]
Vital ACP, Croge C, da Silva DF, Araújo PJ, Gallina MZ, Matumoto-Pintro PT. Okara residue as source of antioxidants against lipid oxidation in milk enriched with omega-3 and bioavailability of bioactive compounds after in vitro gastrointestinal digestion. J Food Sci Technol 2018; 55(4): 1518-24.
[http://dx.doi.org/10.1007/s13197-018-3069-2] [PMID: 29606766]
[67]
Kuffa M, Priesbe TJ, Krueger CG, Reed JD, Richards MP. Ability of dietary antioxidants to affect lipid oxidation of cooked turkey meat in a simulated stomach and blood lipids after a meal. J Funct Foods 2009; 1(2): 208-16.
[http://dx.doi.org/10.1016/j.jff.2009.01.010]
[68]
Monde A, Carbonneau MA, Michel F, et al. Potential health implication of in vitro human low-density lipoprotein-vitamin E oxidation modulation by polyphenols derived from Côte d’Ivoire’s oil palm species. J Agric Food Chem 2011; 59(17): 9166-71.
[http://dx.doi.org/10.1021/jf201658g] [PMID: 21707032]
[69]
Halliwell B, Zhao K, Whiteman M. The gastrointestinal tract: A major site of antioxidant action? Free Radic Res 2000; 33(6): 819-30.
[http://dx.doi.org/10.1080/10715760000301341] [PMID: 11237104]
[70]
Lorrain B, Dangles O, Loonis M, Armand M, Dufour C. Dietary iron-initiated lipid oxidation and its inhibition by polyphenols in gastric conditions. J Agric Food Chem 2012; 60(36): 9074-81.
[http://dx.doi.org/10.1021/jf302348s] [PMID: 22860567]
[71]
Rotta EM, Giroux HJ, Lamothe S, et al. Use of passion fruit seed extract (Passiflora edulis Sims) to prevent lipid oxidation in dairy beverages during storage and simulated digestion. Lebensm Wiss Technol 2020; 123: 109088.
[http://dx.doi.org/10.1016/j.lwt.2020.109088]
[72]
Lorenzo JM, Pateiro M, Domínguez R, et al. Berries extracts as natural antioxidants in meat products: A review. Food Res Int 2018; 106: 1095-104.
[http://dx.doi.org/10.1016/j.foodres.2017.12.005] [PMID: 29579903]
[73]
Azofeifa G, Quesada S, Pérez A, Vaillant F, Michel A. Effect of an in vitro digestion on the antioxidant capacity of a microfiltrated blackberry juice (Rubus adenotrichos). Beverages 2018; 4(2): 30-42.
[http://dx.doi.org/10.3390/beverages4020030]
[74]
Hu D, Xu Y, Xie J, Sun C, Zheng X, Chen W. Systematic evaluation of phenolic compounds and protective capacity of a new mulberry cultivar J33 against palmitic acid-induced lipotoxicity using a simulated digestion method. Food Chem 2018; 258: 43-50.
[http://dx.doi.org/10.1016/j.foodchem.2018.03.049] [PMID: 29655752]
[75]
Dairi S, Madani K, Aoun M, et al. Antioxidative properties and ability of phenolic compounds of Myrtus communis leaves to counteract in vitro LDL and phospholipid aqueous dispersion oxidation. J Food Sci 2014; 79(7): C1260-70.
[http://dx.doi.org/10.1111/1750-3841.12517] [PMID: 24962212]
[76]
Martin-Rubio AS, Sopelana P, Guillén MD. Influence of minor components on lipid bioaccessibility and oxidation during in vitro digestion of soybean oil. J Sci Food Agric 2019; 99(10): 4793-800.
[http://dx.doi.org/10.1002/jsfa.9734] [PMID: 30977133]
[77]
Nieva-Echevarría B, Goicoechea E, Guillén MD. Effect of adding alpha-tocopherol on the oxidation advance during in vitro gastrointestinal digestion of sunflower and flaxseed oils. Food Res Int 2019; 125: 108558.
[http://dx.doi.org/10.1016/j.foodres.2019.108558] [PMID: 31554043]
[78]
Dairi S, Carbonneau MA, Galeano-Diaz T, et al. Antioxidant effects of extra virgin olive oil enriched by myrtle phenolic extracts on iron-mediated lipid peroxidation under intestinal conditions model. Food Chem 2017; 237: 297-304.
[http://dx.doi.org/10.1016/j.foodchem.2017.04.106] [PMID: 28763999]
[79]
Hidalgo M, Sánchez-Moreno C, de Pascual-Teresa S. Flavonoid–flavonoid interaction and its effect on their antioxidant activity. Food Chem 2010; 121(3): 691-6.
[http://dx.doi.org/10.1016/j.foodchem.2009.12.097]
[80]
Raes K, Doolaege EHA, Deman S, Vossen E, De Smet S. Effect of carnosic acid, quercetin and α-tocopherol on lipid and protein oxidation in an in vitro simulated gastric digestion model. Int J Food Sci Nutr 2015; 66(2): 216-21.
[http://dx.doi.org/10.3109/09637486.2014.959900] [PMID: 25578758]
[81]
Rysman T, Van Hecke T, De Smet S, Van Royen G. Ascorbate and apple phenolics affect protein oxidation in emulsion-type sausages during storage and in vitro digestion. J Agric Food Chem 2016; 64(20): 4131-8.
[http://dx.doi.org/10.1021/acs.jafc.6b00437] [PMID: 27133801]
[82]
Ranawana V, Moynihan E, Campbell F, Duthie G, Raikos V. Beetroot improves oxidative stability and functional properties of processed foods: Singular and combined effects with chocolate. J Food Sci Technol 2018; 55(7): 2401-9.
[http://dx.doi.org/10.1007/s13197-018-3157-3] [PMID: 30042555]
[83]
Wang HY, Qian H, Yao WR. Melanoidins produced by the Maillard reaction: Structure and biological activity. Food Chem 2011; 128(3): 573-84.
[http://dx.doi.org/10.1016/j.foodchem.2011.03.075]
[84]
Tagliazucchi D, Verzelloni E, Conte A. Effect of dietary melanoidins on lipid peroxidation during simulated gastric digestion: Their possible role in the prevention of oxidative damage. J Agric Food Chem 2010; 58(4): 2513-9.
[http://dx.doi.org/10.1021/jf903701h] [PMID: 20070103]
[85]
Verzelloni E, Tagliazucchi D, Conte A. From balsamic to healthy: Traditional balsamic vinegar melanoidins inhibit lipid peroxidation during simulated gastric digestion of meat. Food Chem Toxicol 2010; 48(8-9): 2097-102.
[http://dx.doi.org/10.1016/j.fct.2010.05.010] [PMID: 20470852]
[86]
Sarmadi BH, Ismail A. Antioxidative peptides from food proteins: A review. Peptides 2010; 31(10): 1949-56.
[http://dx.doi.org/10.1016/j.peptides.2010.06.020] [PMID: 20600423]
[87]
Hur SJ, Lim BO, Decker EA, McClements DJ. in vitro human digestion models for food applications. Food Chem 2011; 125(1): 1-12.
[http://dx.doi.org/10.1016/j.foodchem.2010.08.036]
[88]
Lamothe S, Guérette C, Dion F, Sabik H, Britten M. Antioxidant activity of milk and polyphenol-rich beverages during simulated gastrointestinal digestion of linseed oil emulsions. Food Res Int 2019; 122: 149-56.
[http://dx.doi.org/10.1016/j.foodres.2019.03.068] [PMID: 31229066]
[89]
Lamothe S, Desroches V, Britten M. Effect of milk proteins and food-grade surfactants on oxidation of linseed oil-in-water emulsions during in vitro digestion. Food Chem 2019; 294: 130-7.
[http://dx.doi.org/10.1016/j.foodchem.2019.04.107] [PMID: 31126445]
[90]
Corrochano AR, Sariçay Y, Arranz E, Kelly PM, Buckin V, Giblin L. Comparison of antioxidant activities of bovine whey proteins before and after simulated gastrointestinal digestion. J Dairy Sci 2019; 102(1): 54-67.
[http://dx.doi.org/10.3168/jds.2018-14581] [PMID: 30527978]
[91]
Nieva-Echevarría B, Goicoechea E, Guillén MD. Effect of the presence of protein on lipolysis and lipid oxidation occurring during in vitro digestion of highly unsaturated oils. Food Chem 2017; 235: 21-33.
[http://dx.doi.org/10.1016/j.foodchem.2017.05.028] [PMID: 28554628]
[92]
Borawska J, Darewicz M, Vegarud GE, Iwaniak A, Minkiewicz P. Ex vivo digestion of carp muscle tissue – ACE inhibitory and antioxidant activities of the obtained hydrolysates. Food Funct 2015; 6(1): 210-7.
[http://dx.doi.org/10.1039/C4FO00621F] [PMID: 25367247]
[93]
Nieva-Echevarría B, Manzanos MJ, Goicoechea E, Guillén MD. 2, 6-Di-tert-butyl-hydroxytoluene and its metabolites in foods. Compr Rev Food Sci Food Saf 2015; 14(1): 67-80.
[http://dx.doi.org/10.1111/1541-4337.12121] [PMID: 33401811]
[94]
Nieva-Echevarría B, Goicoechea E, Guillén MD. Polyunsaturated lipids and vitamin A oxidation during cod liver oil in vitro gastrointestinal digestion. Antioxidant effect of added BHT. Food Chem 2017; 232: 733-43.
[http://dx.doi.org/10.1016/j.foodchem.2017.04.057] [PMID: 28490135]
[95]
Tarvainen M, Phuphusit A, Suomela JP, Kuksis A, Kallio H. Effects of antioxidants on rapeseed oil oxidation in an artificial digestion model analyzed by UHPLC-ESI-MS. J Agric Food Chem 2012; 60(14): 3564-79.
[http://dx.doi.org/10.1021/jf2050944] [PMID: 22433015]
[96]
Fan Y, Liu Y, Gao L, Zhang Y, Yi J. Oxidative stability and in vitro digestion of menhaden oil emulsions with whey protein: Effects of EGCG conjugation and interfacial cross-linking. Food Chem 2018; 265: 200-7.
[http://dx.doi.org/10.1016/j.foodchem.2018.05.098] [PMID: 29884373]
[97]
Kenmogne-Domguia HB, Meynier A, Boulanger C, Genot C. Lipid oxidation in food emulsions under gastrointestinal-simulated conditions: The key role of endogenous tocopherols and initiator. Food Dig 2012; 3(1-3): 46-52.
[http://dx.doi.org/10.1007/s13228-012-0026-9]

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