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Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Review Article

The Hypermetabolic Response to Burns and its Treatment: A Literature Review

Author(s): Madeline Houschyar*, Mimi R. Borrelli, Christian Tapking, Behrus Puladi, Mark Ooms, Zeshaan N. Maan, Clifford C. Sheckter, Susanne Rein, Georg Reumuth, Kristian Weissenberg, Constantin Weil, Dominik Duscher, Dominik Pförringer, Frank Siemers, Björn Behr, Marcus Lehnhardt and Khosrow S. Houschyar

Volume 19, Issue 7, 2023

Published on: 29 December, 2022

Page: [682 - 691] Pages: 10

DOI: 10.2174/1573401319666221115100441

Price: $65

Abstract

Major burn injuries provoke a profound stress response marked by extreme hypermetabolism and impaired immune function. The physiological alterations to glucose, protein and lipid metabolism can be detected even years after the inciting burns injury and when untreated can lead to profound wasting, fatty liver, and even death. Therapeutic strategies which target these physiological disturbances are of paramount importance. Treating burn injuries begins with active cooling, to minimize loss of heat and water, and nutrition, to counteract the extensive catabolism. Providers should follow the strict guidelines published to ensure caloric requirements are met in adult and pediatric patients, with supplementation as indicated. Several pharmacotherapies have proven beneficial in helping to counteract and reverse these physiological changes by lowering insulin resistance, slowing catabolism, and minimizing loss of lean body mass. The most promising drugs include anabolic agents such as insulin, recombinant human growth hormone (rhGH), insulin-like growth factor 1 (IGF-1), metformin, beta-blockers, oxandrolone, and fenofibrate. Surgery is a necessary adjunct, either in the acute phase to debride compromised soft tissue and prevent compartment syndromes, but also in the chronic setting to release contractures and fibrotic strictures which may impair function. This narrative literature review provides a synopsis of our understanding of the hypermetabolic response to burn injury and discusses the different treatment options aiming to control postburn hypermetabolism and ultimately improve patient outcomes.

Graphical Abstract

[1]
Rousseau AF, Losser MR, Ichai C, Berger MM. ESPEN endorsed recommendations: Nutritional therapy in major burns. Clin Nutr 2013; 32(4): 497-502.
[http://dx.doi.org/10.1016/j.clnu.2013.02.012] [PMID: 23582468]
[2]
Foncerrada G, Culnan DM, Capek KD, et al. Inhalation Injury in the Burned Patient. Ann Plast Surg 2018; 80(3)(S2): S98-S105.
[http://dx.doi.org/10.1097/SAP.0000000000001377] [PMID: 29461292]
[3]
Norbury WB, Herndon DN, Branski LK, Chinkes DL, Jeschke MG. Urinary cortisol and catecholamine excretion after burn injury in children. J Clin Endocrinol Metab 2008; 93(4): 1270-5.
[http://dx.doi.org/10.1210/jc.2006-2158] [PMID: 18211976]
[4]
Elke G, Kott M, Weiler N. When and how should sepsis patients be fed? Curr Opin Clin Nutr Metab Care 2015; 18(2): 169-78.
[http://dx.doi.org/10.1097/MCO.0000000000000151] [PMID: 25635596]
[5]
Rojas Y, Finnerty CC, Radhakrishnan RS, Herndon DN. Burns: An update on current pharmacotherapy. Expert Opin Pharmacother 2012; 13(17): 2485-94.
[http://dx.doi.org/10.1517/14656566.2012.738195] [PMID: 23121414]
[6]
Upperman JS, Bucuvalas JC, Williams FN, et al. Specific etiologies associated with the multiple organ dysfunction syndrome in children. Pediatr Crit Care Med 2017; 18(3)(S1): S58-66.
[http://dx.doi.org/10.1097/PCC.0000000000001051] [PMID: 28248835]
[7]
Williams FN, Herndon DN, Jeschke MG. The hypermetabolic response to burn injury and interventions to modify this response. Clin Plast Surg 2009; 36(4): 583-96.
[http://dx.doi.org/10.1016/j.cps.2009.05.001] [PMID: 19793553]
[8]
Auger C, Samadi O, Jeschke MG. The biochemical alterations underlying post-burn hypermetabolism. Biochim Biophys Acta Mol Basis Dis 2017; 1863(10): 2633-44.
[http://dx.doi.org/10.1016/j.bbadis.2017.02.019] [PMID: 28219767]
[9]
Jeschke MG. The hepatic response to thermal injury: Is the liver important for postburn outcomes? Mol Med 2009; 15(9-10): 337-51.
[http://dx.doi.org/10.2119/molmed.2009.00005] [PMID: 19603107]
[10]
Kaddoura I, Abu-Sittah G, Ibrahim A, Karamanoukian R, Papazian N. Burn injury: Review of pathophysiology and therapeutic modalities in major burns. Ann Burns Fire Disasters 2017; 30(2): 95-102.
[PMID: 29021720]
[11]
Şimşek T, Uzelli Simsek H, Cantürk NZ. Response to trauma and metabolic changes: Posttraumatic metabolism. Ulus Cerrahi Derg 2014; 30(3): 153-9.
[http://dx.doi.org/10.5152/UCD.2014.2653] [PMID: 25931917]
[12]
Kitabchi AE, Temprosa M, Knowler WC, et al. Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: Effects of lifestyle intervention and metformin. Diabetes 2005; 54(8): 2404-14.
[http://dx.doi.org/10.2337/diabetes.54.8.2404] [PMID: 16046308]
[13]
Williams FN, Jeschke MG, Chinkes DL, Suman OE, Branski LK, Herndon DN. Modulation of the hypermetabolic response to trauma: Temperature, nutrition, and drugs. J Am Coll Surg 2009; 208(4): 489-502.
[http://dx.doi.org/10.1016/j.jamcollsurg.2009.01.022] [PMID: 19476781]
[14]
Gauglitz GG, Herndon DN, Jeschke MG. Insulin resistance postburn: Underlying mechanisms and current therapeutic strategies. J Burn Care Res 2008; 29(5): 683-94.
[http://dx.doi.org/10.1097/BCR.0b013e31818481ce] [PMID: 18695610]
[15]
HsüAi H. Ch’in T, Tong C. Hyperglycaemia after burn injury. Burns 1989; 15(3): 145-6.
[http://dx.doi.org/10.1016/0305-4179(89)90168-X] [PMID: 2667559]
[16]
Jeschke MG. Clinical review: Glucose control in severely burned patients - current best practice. Crit Care 2013; 17(4): 232.
[http://dx.doi.org/10.1186/cc12678] [PMID: 23890278]
[17]
Jeschke MG, Pinto R, Herndon DN, Finnerty CC, Kraft R. Hypoglycemia is associated with increased postburn morbidity and mortality in pediatric patients. Crit Care Med 2014; 42(5): 1221-31.
[http://dx.doi.org/10.1097/CCM.0000000000000138] [PMID: 24368343]
[18]
Kamolz LP, Pieber T, Smolle-Jüttner FM, Lumenta DB. Optimal blood glucose control in severely burned patients: A long way to go, but one step closer. Crit Care 2013; 17(5): 1005.
[http://dx.doi.org/10.1186/cc12733] [PMID: 24107553]
[19]
Pham TN, Warren AJ, Phan HH, Molitor F, Greenhalgh DG, Palmieri TL. Impact of tight glycemic control in severely burned children. J Trauma 2005; 59(5): 1148-54.
[http://dx.doi.org/10.1097/01.ta.0000188933.16637.68] [PMID: 16385293]
[20]
Mecott GA, Al-Mousawi AM, Gauglitz GG, Herndon DN, Jeschke MG. The role of hyperglycemia in burned patients: Evidence-based studies. Shock 2010; 33(1): 5-13.
[http://dx.doi.org/10.1097/SHK.0b013e3181af0494] [PMID: 19503020]
[21]
Gore DC, Wolf SE, Herndon DN, Wolfe RR. Metformin blunts stress-induced hyperglycemia after thermal injury. J Trauma 2003; 54(3): 555-61.
[http://dx.doi.org/10.1097/01.TA.0000026990.32856.58] [PMID: 12634538]
[22]
Pen X. Further understanding of the hypermetabolism mechanism in burn injury and the strategy of regulation and control. Zhonghua Shao Shang Za Zhi 2013; 29(2): 139-43.
[PMID: 23985201]
[23]
Jeschke MG, Finnerty CC, Herndon DN, et al. Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response. Ann Surg 2012; 255(2): 370-8.
[http://dx.doi.org/10.1097/SLA.0b013e31823e76e7] [PMID: 22241293]
[24]
Jeschke MG. Postburn hypermetabolism. J Burn Care Res 2016; 37(2): 86-96.
[http://dx.doi.org/10.1097/BCR.0000000000000265] [PMID: 26132047]
[25]
Herndon DN, Ramzy PI, DebRoy MA, et al. Muscle protein catabolism after severe burn: Effects of IGF-1/IGFBP-3 treatment. Ann Surg 1999; 229(5): 713-20.
[http://dx.doi.org/10.1097/00000658-199905000-00014] [PMID: 10235530]
[26]
Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections. Clin Microbiol Rev 2006; 19(2): 403-34.
[http://dx.doi.org/10.1128/CMR.19.2.403-434.2006] [PMID: 16614255]
[27]
Williams FN, Branski LK, Jeschke MG, Herndon DN. What, how, and how much should patients with burns be fed? Surg Clin North Am 2011; 91(3): 609-29.
[http://dx.doi.org/10.1016/j.suc.2011.03.002] [PMID: 21621699]
[28]
Atiyeh BS, Gunn SW, Dibo SA. Nutritional and pharmacological modulation of the metabolic response of severely burned patients: Review of the literature (Part II)*. Ann Burns Fire Disasters 2008; 21(3): 119-23.
[PMID: 21991122]
[29]
Hall K, Shahrokhi S, Jeschke M. Enteral nutrition support in burn care: A review of current recommendations as instituted in the Ross Tilley Burn Centre. Nutrients 2012; 4(11): 1554-65.
[http://dx.doi.org/10.3390/nu4111554] [PMID: 23201833]
[30]
Flegal KM, Kit BK, Graubard BI. Body mass index categories in observational studies of weight and risk of death. Am J Epidemiol 2014; 180(3): 288-96.
[http://dx.doi.org/10.1093/aje/kwu111] [PMID: 24893710]
[31]
Schweiger M, Eichmann TO, Taschler U, Zimmermann R, Zechner R, Lass A. Measurement of Lipolysis. Methods Enzymol 2014; 538: 171-93.
[http://dx.doi.org/10.1016/B978-0-12-800280-3.00010-4] [PMID: 24529439]
[32]
Kraft R, Herndon DN, Finnerty CC, Hiyama Y, Jeschke MG. Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children. J Clin Endocrinol Metab 2013; 98(1): 314-21.
[http://dx.doi.org/10.1210/jc.2012-2599] [PMID: 23150682]
[33]
Ballian N, Rabiee A, Andersen DK, Elahi D, Gibson BR. Glucose metabolism in burn patients: The role of insulin and other endocrine hormones. Burns 2010; 36(5): 599-605.
[http://dx.doi.org/10.1016/j.burns.2009.11.008] [PMID: 20074859]
[34]
Samuel VT, Shulman GI. The pathogenesis of insulin resistance: Integrating signaling pathways and substrate flux. J Clin Invest 2016; 126(1): 12-22.
[http://dx.doi.org/10.1172/JCI77812] [PMID: 26727229]
[35]
Sears B, Perry M. The role of fatty acids in insulin resistance. Lipids Health Dis 2015; 14(1): 121.
[http://dx.doi.org/10.1186/s12944-015-0123-1] [PMID: 26415887]
[36]
Jeschke MG, Patsouris D, Stanojcic M, et al. Pathophysiologic response to burns in the elderly. EBioMedicine 2015; 2(10): 1535-48.
[http://dx.doi.org/10.1016/j.ebiom.2015.07.040] [PMID: 26629550]
[37]
Kelemen JJ III, Cioffi WG Jr, Mason AD Jr, Mozingo DW, McManus WF, Pruitt BA Jr. Effect of ambient temperature on metabolic rate after thermal injury. Ann Surg 1996; 223(4): 406-12.
[http://dx.doi.org/10.1097/00000658-199604000-00009] [PMID: 8633919]
[38]
Rivers EP, Ahrens T. Improving outcomes for severe sepsis and septic shock: Tools for early identification of at-risk patients and treatment protocol implementation. Crit Care Clin 2008; 24(3): 1-47.
[http://dx.doi.org/10.1016/j.ccc.2008.04.002] [PMID: 18634996]
[39]
Herndon DN, Spies M. Modern burn care. Semin Pediatr Surg 2001; 10(1): 28-31.
[http://dx.doi.org/10.1053/spsu.2001.19389] [PMID: 11172570]
[40]
Borhani-Khomani K, Vestergaard MR, Holmgaard R. Handling of hypermetabolism in major burn injuries. Ugeskr Laeger 2018; 180(17): V10170802.
[PMID: 29717705]
[41]
Hildreth MA, Herndon DN, Desai MH, Broemeling LD. Caloric requirements of patients with burns under one year of age. J Burn Care Rehabil 1993; 14(1): 108-12.
[http://dx.doi.org/10.1097/00004630-199301000-00023] [PMID: 8454656]
[42]
Royall D, Fairholm L, Peters WJ, Jeejeebhoy KN, Allard JP. Continuous measurement of energy expenditure in ventilated burn patients. Crit Care Med 1994; 22(3): 399-406.
[http://dx.doi.org/10.1097/00003246-199403000-00008] [PMID: 8124989]
[43]
Hildreth MA, Herndon DN, Desai MH, Duke MA. Reassessing caloric requirements in pediatric burn patients. J Burn Care Rehabil 1988; 9(6): 616-8.
[http://dx.doi.org/10.1097/00004630-198811000-00009] [PMID: 3146576]
[44]
Hart DW, Wolf SE, Herndon DN, et al. Energy expenditure and caloric balance after burn: Increased feeding leads to fat rather than lean mass accretion. Ann Surg 2002; 235(1): 152-61.
[http://dx.doi.org/10.1097/00000658-200201000-00020] [PMID: 11753055]
[45]
Kreymann G, Adolph M, Mueller MJ. Energy expenditure and energy intake - guidelines on parenteral nutrition, Chapter 3. Ger Med Sci 2009; 7: Doc25.
[PMID: 20049085]
[46]
Gray A. Nutritional Recommendations for Individuals with Diabetes Endotext South Dartmouth (MA): MDTextcom, Inc. 2000.
[PMID: 25905243]
[47]
Prelack K, Dylewski M, Sheridan RL. Practical guidelines for nutritional management of burn injury and recovery. Burns 2007; 33(1): 14-24.
[http://dx.doi.org/10.1016/j.burns.2006.06.014] [PMID: 17116370]
[48]
Clark A, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns Trauma 2017; 5(11): 11.
[PMID: 28428966]
[49]
Rodriguez NA, Jeschke MG, Williams FN, Kamolz LP, Herndon DN. Nutrition in Burns. JPEN J Parenter Enteral Nutr 2011; 35(6): 704-14.
[http://dx.doi.org/10.1177/0148607111417446] [PMID: 21975669]
[50]
Mochizuki H, Trocki O, Dominioni L, Brackett KA, Joffe SN, Alexander JW. Mechanism of prevention of postburn hypermetabolism and catabolism by early enteral feeding. Ann Surg 1984; 200(3): 297-310.
[http://dx.doi.org/10.1097/00000658-198409000-00007] [PMID: 6431918]
[51]
Hart DW. Efficacy of a high-carbohydrate diet in catabolic illness. Crit Care Med. Crit Care Med 2001; 29(7): 1318-24.
[52]
Ahuja RB. ISBI practice guidelines for burn care. Burns 2016; 42(5): 951-2.
[http://dx.doi.org/10.1016/j.burns.2016.06.020] [PMID: 27542292]
[53]
Alexander JW, MacMillan BG, Stinnett JD, et al. Beneficial effects of aggressive protein feeding in severely burned children. Ann Surg 1980; 192(4): 505-17.
[http://dx.doi.org/10.1097/00000658-198010000-00009] [PMID: 7425697]
[54]
Hampton V, Hampton T, Dheansa B, Falder S, Emery P. Evaluation of high protein intake to improve clinical outcome and nutritional status for patients with burns: A systematic review. Burns 2021; 47(8): 1714-29.
[http://dx.doi.org/10.1016/j.burns.2021.02.028] [PMID: 33722450]
[55]
Yu YM, Ryan CM, Burke JF, Tompkins RG, Young VR. Relations among arginine, citrulline, ornithine, and leucine kinetics in adult burn patients. Am J Clin Nutr 1995; 62(5): 960-8.
[http://dx.doi.org/10.1093/ajcn/62.5.960] [PMID: 7572742]
[56]
Wolfe RR, Goodenough RD, Burke JF, Wolfe MH. Response of protein and urea kinetics in burn patients to different levels of protein intake. Ann Surg 1983; 197(2): 163-71.
[http://dx.doi.org/10.1097/00000658-198302000-00007] [PMID: 6824370]
[57]
Matthews DE, Marano MA, Campbell RG. Splanchnic bed utilization of leucine and phenylalanine in humans. Am J Physiol 1993; 264(1 Pt 1): E109-18.
[PMID: 8430779]
[58]
Patterson BW, Nguyen T, Pierre E, Herndon DN, Wolfe RR. Urea and protein metabolism in burned children: Effect of dietary protein intake. Metabolism 1997; 46(5): 573-8.
[http://dx.doi.org/10.1016/S0026-0495(97)90196-7] [PMID: 9160826]
[59]
Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma 2001; 51(3): 540-4.
[http://dx.doi.org/10.1097/00005373-200109000-00021] [PMID: 11535907]
[60]
Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345(19): 1359-67.
[http://dx.doi.org/10.1056/NEJMoa011300] [PMID: 11794168]
[61]
Herndon DN, Barrow R, Kunkel KR, Broemeling L, Rutan RL. Effects of recombinant human growth hormone on donor-site healing in severely burned children. Ann Surg 1990; 212(4): 424-31.
[http://dx.doi.org/10.1097/00000658-199010000-00005] [PMID: 2121109]
[62]
Barret JP, Dziewulski P, Jeschke MG, Wolf SE, Herndon DN. Effects of recombinant human growth hormone on the development of burn scarring. Plast Reconstr Surg 1999; 104(3): 726-9.
[http://dx.doi.org/10.1097/00006534-199909010-00017] [PMID: 10456525]
[63]
Chrysopoulo MT, Barrow RE, Muller M, Rubin S, Barrow LN, Herndon DN. Chest radiographic appearances in severely burned adults. A comparison of early radiographic and extravascular lung thermal volume changes. J Burn Care Rehabil 2001; 22(2): 104-10.
[http://dx.doi.org/10.1097/00004630-200103000-00004] [PMID: 11302596]
[64]
Jeschke MG, Barrow RE, Herndon DN. Recombinant human growth hormone treatment in pediatric burn patients and its role during the hepatic acute phase response. Crit Care Med 2000; 28(5): 1578-84.
[http://dx.doi.org/10.1097/00003246-200005000-00053] [PMID: 10834715]
[65]
Ramirez RJ, Wolf SE, Barrow RE, Herndon DN. Growth hormone treatment in pediatric burns: A safe therapeutic approach. Ann Surg 1998; 228(4): 439-48.
[http://dx.doi.org/10.1097/00000658-199810000-00001] [PMID: 9790334]
[66]
Takagi K, Suzuki F, Barrow RE, Wolf SE, Kobayashi M, Herndon DN. Growth hormone improves immune function and survival in burned mice infected with herpes simplex virus type 1. J Surg Res 1997; 69(1): 166-70.
[http://dx.doi.org/10.1006/jsre.1997.5066] [PMID: 9202664]
[67]
Mlcak RP, Suman OE, Murphy K, Herndon DN. Effects of growth hormone on anthropometric measurements and cardiac function in children with thermal injury. Burns 2005; 31(1): 60-6.
[http://dx.doi.org/10.1016/j.burns.2004.08.006] [PMID: 15639367]
[68]
Low JFA, Herndon DN, Barrow RE. Effect of growth hormone on growth delay in burned children: A 3-year follow-up study. Lancet 1999; 354(9192): 1789.
[http://dx.doi.org/10.1016/S0140-6736(99)02741-5] [PMID: 10577644]
[69]
Singh KP, Prasad R, Chari PS, Dash RJ. Effect of growth hormone therapy in burn patients on conservative treatment. Burns 1998; 24(8): 733-8.
[http://dx.doi.org/10.1016/S0305-4179(98)00113-2] [PMID: 9915674]
[70]
Takala J, Ruokonen E, Webster NR, et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 1999; 341(11): 785-92.
[http://dx.doi.org/10.1056/NEJM199909093411102] [PMID: 10477776]
[71]
Thompson JL, Butterfield GE, Marcus R, et al. The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J Clin Endocrinol Metab 1995; 80(6): 1845-52.
[PMID: 7539817]
[72]
Heszele MFC, Price SR. Insulin-like growth factor I: The yin and yang of muscle atrophy. Endocrinology 2004; 145(11): 4803-5.
[http://dx.doi.org/10.1210/en.2004-1037] [PMID: 15489312]
[73]
Elijah IE, Branski LK, Finnerty CC, Herndon DN. The GH/IGF-1 system in critical illness. Best Pract Res Clin Endocrinol Metab 2011; 25(5): 759-67.
[http://dx.doi.org/10.1016/j.beem.2011.06.002] [PMID: 21925076]
[74]
Nijsten MWN, Olinga P. The HT, et al. Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Crit Care Med 2000; 28(2): 458-61.
[http://dx.doi.org/10.1097/00003246-200002000-00028] [PMID: 10708183]
[75]
Clemmons DR, Moses AC, McKay MJ, Sommer A, Rosen DM, Ruckle J. The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: Evidence for in vivo biological activity. J Clin Endocrinol Metab 2000; 85(4): 1518-24.
[PMID: 10770191]
[76]
Chaudhury A, Duvoor C, Reddy Dendi VS, et al. Clinical review of antidiabetic drugs: Implications for type 2 diabetes mellitus management. Front Endocrinol 2017; 8(8): 6.
[http://dx.doi.org/10.3389/fendo.2017.00006] [PMID: 28167928]
[77]
Viollet B, Foretz M. Revisiting the mechanisms of metformin action in the liver Annales d’endocrinologie. Elsevier 2013.
[http://dx.doi.org/10.1016/j.ando.2013.03.006]
[78]
Maghsoudi H, Aghamohammadzadeh N, Khalili N. Burns in diabetic patients. Int J Diabetes Dev Ctries 2008; 28(1): 19-25.
[http://dx.doi.org/10.4103/0973-3930.41982] [PMID: 19902035]
[79]
Gore DC, Wolf SE, Sanford A, Herndon DN, Wolfe RR. Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. Ann Surg 2005; 241(2): 334-42.
[http://dx.doi.org/10.1097/01.sla.0000152013.23032.d1] [PMID: 15650645]
[80]
Greabu M, Badoiu SC, Stanescu-Spinu II, et al. Drugs interfering with insulin resistance and their influence on the associated hypermetabolic state in severe burns: A narrative review. Int J Mol Sci 2021; 22(18): 9782.
[http://dx.doi.org/10.3390/ijms22189782] [PMID: 34575946]
[81]
Staels B. Metformin and pioglitazone: Effectively treating insulin resistance. Curr Med Res Opin 2006; 22(S2): S27-37.
[http://dx.doi.org/10.1185/030079906X112732] [PMID: 16914073]
[82]
Gauglitz GG, Williams FN, Herndon DN, Jeschke MG. Burns: Where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs? Curr Opin Clin Nutr Metab Care 2011; 14(2): 176-81.
[http://dx.doi.org/10.1097/MCO.0b013e3283428df1] [PMID: 21157309]
[83]
Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG. Burns. J Burn Care Res 2017; 38(1): e469-81.
[http://dx.doi.org/10.1097/BCR.0000000000000355] [PMID: 27183443]
[84]
Barisione G, Baroffio M, Crimi E, Brusasco V. Beta-Adrenergic Agonists. Pharmaceuticals 2010; 3(4): 1016-44.
[http://dx.doi.org/10.3390/ph3041016] [PMID: 27713285]
[85]
Núñez-Villaveirán T, Sánchez M, Millán P, García-de-Lorenzo A. Systematic review of the effect of propanolol on hypermetabolism in burn injuries. Med Intensiva 2015; 39(2): 101-13.
[http://dx.doi.org/10.1016/j.medine.2015.02.003] [PMID: 25305241]
[86]
Herndon DN, Rodriguez NA, Diaz EC, et al. Long-term propranolol use in severely burned pediatric patients: A randomized controlled study. Ann Surg 2012; 256(3): 402-11.
[http://dx.doi.org/10.1097/SLA.0b013e318265427e] [PMID: 22895351]
[87]
Kopel J. Application of beta-blockers in burn management. Proc Bayl Univ Med Cent 2022; 35(1): 46-50.
[http://dx.doi.org/10.1080/08998280.2021.2002110]
[88]
Ferrando AA, Tipton KD, Doyle D, Phillips SM, Cortiella J, Wolfe RR. Testosterone injection stimulates net protein synthesis but not tissue amino acid transport. Am J Physiol 1998; 275(5): E864-71.
[PMID: 9815007]
[89]
Hart DW, Wolf SE, Ramzy PI, et al. Anabolic effects of oxandrolone after severe burn. Ann Surg 2001; 233(4): 556-64.
[http://dx.doi.org/10.1097/00000658-200104000-00012] [PMID: 11303139]
[90]
Jeschke MG, Finnerty CC, Suman OE, Kulp G, Mlcak RP, Herndon DN. The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg 2007; 246(3): 351-62.
[http://dx.doi.org/10.1097/SLA.0b013e318146980e] [PMID: 17717439]
[91]
Przkora R, Jeschke MG, Barrow RE, et al. Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment. Ann Surg 2005; 242(3): 384-91.
[http://dx.doi.org/10.1097/01.sla.0000180398.70103.24] [PMID: 16135924]
[92]
Cree MG, Zwetsloot JJ, Herndon DN, et al. Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg 2007; 245(2): 214-21.
[http://dx.doi.org/10.1097/01.sla.0000250409.51289.ca] [PMID: 17245174]
[93]
Minnich A, Tian N, Byan L, Bilder G. A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle. Am J Physiol Endocrinol Metab 2001; 280(2): E270-9.
[http://dx.doi.org/10.1152/ajpendo.2001.280.2.E270] [PMID: 11158930]
[94]
Cancio LC, Barillo DJ, Kearns RD, et al. Guidelines for burn care under austere conditions: Surgical and nonsurgical wound management. J Burn Care Res 2017; 38(4): 203-14.
[http://dx.doi.org/10.1097/BCR.0000000000000368] [PMID: 27355660]
[95]
Tompkins RG, Remensnyder JP, Burke JF, et al. Significant reductions in mortality for children with burn injuries through the use of prompt eschar excision. Ann Surg 1988; 208(5): 577-85.
[http://dx.doi.org/10.1097/00000658-198811000-00006] [PMID: 3190284]

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Request history8.2.27PHP Version1.03sRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[20:50:08] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[20:50:09] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
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  • Booting (237ms)time
  • Application (796ms)time
  • 1 x Application (77.04%)
    796ms
    1 x Booting (22.95%)
    237ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    36 statements were executed, 4 of which were duplicates, 32 unique. Show only duplicated651ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314333023','',1,1740775808,1740775808) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740775808
      10.5msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314333023','/article/127571',1,1740775808,1740775808)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314333023 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314333023) limit 1
      86.65msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314333023
      • 1: 314333023
      • 2: 314333023
      • 3: 314333023
      • 4: 314333023
      • 5: 314333023
      • 6: 314333023
      • 7: 314333023
      • 8: 314333023
      • 9: 314333023
      • 10: 314333023
      • 11: 314333023
      • 12: 314333023
      • 13: 314333023
      • 14: 314333023
      • 15: 314333023
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=127571
      19.54msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 35 limit 1
      12.09msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 35
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=35) and sj.journal_id!=35 group by `j`.`nid`) as `aggregate_table`
      26.72msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=35) and sj.journal_id!=35 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      740μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=35) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      34.13msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=35) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.24msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '127571'
      390μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 127571
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '127571'
      38.99msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 127571
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '127571' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      15.63msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 127571
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      2.1msalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      790μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 35 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      90.66msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 35 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      104msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 35 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      8.55msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 127571 limit 1
      30.09msalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 127571
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 127571 and content_type = 'article' order by status desc limit 1
      26.51msalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 210896 limit 1
      11.01msalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 210896
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      370μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CNF' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      470μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CNF
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '127571' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      12.44msalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12533' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      530μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3362' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      470μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3362) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3362) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3362)
      91.21msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12533) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12533) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12533)
      1.32msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 127571) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 127571) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314333023 and j.to_ip >=314333023 )) and ((j.from_date <= 1740775809 and j.to_date >= 1740775809 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 127571)
      1.09msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '682' and is_uploaded = 1 and issue_id = 12533 order by cast(first_page as SIGNED) desc limit 1
      870μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 682
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '691' and is_uploaded = 1 and issue_id = 12533 order by cast(first_page as SIGNED) asc limit 1
      690μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 691
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      1.84msalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      350μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 127571 limit 1
      3.99msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 127571
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 35 and `b`.`banner_from_date` <= 1740775809 and `b`.`banner_to_date` >= 1740775809 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.7msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 35
      • 3: 1740775809
      • 4: 1740775809
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 35 and `b`.`banner_from_date` <= 1740775809 and `b`.`banner_to_date` >= 1740775809 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      11.65msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 35
      • 3: 1740775809
      • 4: 1740775809
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='8fc69cf95848b6ecb5cf210454efb50a'
      470μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        wIefvPaAtMhfDGpRNMZEptvZNzN5mUdJ6ETyhL4u
        uc_cart_id
        8fc69cf95848b6ecb5cf210454efb50a
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/127571" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/127571
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
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